Sep-tRNA(Sec) is converted to Sec-tRNA(Sec) by PXLP-K284-SEPSECS tetramer

Stable Identifier
R-HSA-2408555
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
H2O + O-phospho-L-seryl-tRNA(Sec) + selenophosphate => L-selenocysteinyl-tRNA(Sec) + 2 phosphate
ReviewStatus
5/5
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Sep-tRNA(Sec) is converted to Sec-tRNA(Sec) by PXLP-K284-SEPSECS tetramer
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O-phosphoseryl-tRNA(Sec) selenium transferase (SEPSECS) tetramer catalyses the transformation of phosphoserine (Sep) into selenocysteine (Sec) by using selenophosphate (SELP) as a selenium donor to convert the phosphoserylated transfer RNA (tRNA) for Sec (Sep-tRNASec) into Sec-tRNASec (Palioura et al. 2009, Yuan et al. 2006).
Literature References
PubMed ID Title Journal Year
17142313 RNA-dependent conversion of phosphoserine forms selenocysteine in eukaryotes and archaea

Yuan, J, Palioura, S, Salazar, JC, Su, D, O'Donoghue, P, Hohn, MJ, Cardoso, AM, Whitman, WB, Söll, D

Proc. Natl. Acad. Sci. U.S.A. 2006
19608919 The human SepSecS-tRNASec complex reveals the mechanism of selenocysteine formation

Palioura, S, Sherrer, RL, Steitz, TA, Söll, D, Simonovic, M

Science 2009
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Catalyst Activity

O-phosphoseryl-tRNA(Sec) selenium transferase activity of PXLP-K284-SEPSECS tetramer [cytosol]

Physical Entity
PXLP-K284-SEPSECS tetramer [cytosol] (Homo sapiens)
Activity
O-phosphoseryl-tRNA(Sec) selenium transferase activity (GO:0098621)
Cross References
RHEA
Authored
Williams, MG  (2014-05-06)
Reviewed
Rush, MG  (2015-08-30)
Hill, DP  (2025-02-25)
Created
Williams, MG  (2012-07-17)
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