Reactome | PTPN3 dephosphorylates EPS15

PTPN3 dephosphorylates EPS15

Stable Identifier

R-HSA-8867047

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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While the roles of EGFR and EPS15 phosphorylation and ubiquitination are not completely clear, recent evidence supports the idea that EGFR-mediated phosphorylation of EPS15 promotes the clustering of the activated receptor into clathrin-coated pits, while the dephosphorylated EPS15 targets EGFR for endocytosis through a caveolin-and lipid raft-dependent route (reviewed in van Bergen en Henegouwen, 2009). Consistent with this, overexpression of the phosphatase PTPN3, which dephosphorylates EPS15 in vitro and in vivo, promotes the internalization of EGFR into caveolin-enriched structures and targets it for lysosomal degradation (Li et al, 2015).

Literature References

PubMed ID	Title	Journal	Year
19814798	Eps15: a multifunctional adaptor protein regulating intracellular trafficking van Bergen En Henegouwen, PM	Cell Commun. Signal	2009
25263444	Protein tyrosine phosphatase PTPN3 inhibits lung cancer cell proliferation and migration by promoting EGFR endocytic degradation Chang, GD, Chou, YT, Chi, AP, Meng, TC, Li, MY, Wu, CW, Mi, YZ, Khoo, KH, Chen, GC, Lai, PL	Oncogene	2015