Reactome | I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane

I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane

Stable Identifier

R-HSA-1855222

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane

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Type I inositol-1,4,5-trisphosphate 5-phosphatase (INPP5A) and the Type II phosphatase (INPP5B) are isoprenylated to the plasma membrane and act as a lipid anchor. Here they dephosphorylate inositol 1,4,5-trisphosphate (I(1,4,5)P3) to inositol 1,4-bisphosphate I(1,4)P2. ).

The following lists the above proteins with their corresponding literature references: INPP5A (Laxminarayan et al. 1994); INPP5B (Jefferson & Majerus 1995, Ross et al. 1991, Schmid et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
8006039	Characterization of a cDNA encoding the 43-kDa membrane-associated inositol-polyphosphate 5-phosphatase Laxminarayan, KM, Chan, BK, Tetaz, T, Bird, PI, Mitchell, CA	J Biol Chem	1994
15474001	Type II phosphoinositide 5-phosphatases have unique sensitivities towards fatty acid composition and head group phosphorylation Schmid, AC, Wise, HM, Mitchell, CA, Nussbaum, R, Woscholski, R	FEBS Lett	2004
7721860	Properties of type II inositol polyphosphate 5-phosphatase Jefferson, AB, Majerus, PW	J Biol Chem	1995
1718960	Cloning and expression of human 75-kDa inositol polyphosphate-5-phosphatase Ross, TS, Jefferson, AB, Mitchell, CA, Majerus, PW	J Biol Chem	1991