Reactome | I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane

I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane

Stable Identifier

R-HSA-1855222

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane

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Type I inositol-1,4,5-trisphosphate 5-phosphatase (INPP5A) and the Type II phosphatase (INPP5B) are isoprenylated to the plasma membrane and act as a lipid anchor. Here they dephosphorylate inositol 1,4,5-trisphosphate (I(1,4,5)P3) to inositol 1,4-bisphosphate I(1,4)P2. ).

The following lists the above proteins with their corresponding literature references: INPP5A (Laxminarayan et al. 1994); INPP5B (Jefferson & Majerus 1995, Ross et al. 1991, Schmid et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
8006039	Characterization of a cDNA encoding the 43-kDa membrane-associated inositol-polyphosphate 5-phosphatase Bird, PI, Chan, BK, Tetaz, T, Mitchell, CA, Laxminarayan, KM	J Biol Chem	1994
15474001	Type II phosphoinositide 5-phosphatases have unique sensitivities towards fatty acid composition and head group phosphorylation Woscholski, R, Schmid, AC, Nussbaum, R, Mitchell, CA, Wise, HM	FEBS Lett	2004
7721860	Properties of type II inositol polyphosphate 5-phosphatase Jefferson, AB, Majerus, PW	J Biol Chem	1995
1718960	Cloning and expression of human 75-kDa inositol polyphosphate-5-phosphatase Ross, TS, Jefferson, AB, Majerus, PW, Mitchell, CA	J Biol Chem	1991