I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane

Stable Identifier
Reaction [transition]
Homo sapiens
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Type I inositol-1,4,5-trisphosphate 5-phosphatase (INPP5A) and the Type II phosphatase (INPP5B) are isoprenylated to the plasma membrane and act as a lipid anchor. Here they dephosphorylate inositol 1,4,5-trisphosphate (I(1,4,5)P3) to inositol 1,4-bisphosphate I(1,4)P2. ).

The following lists the above proteins with their corresponding literature references: INPP5A (Laxminarayan et al. 1994); INPP5B (Jefferson & Majerus 1995, Ross et al. 1991, Schmid et al. 2004).

Literature References
PubMed ID Title Journal Year
8006039 Characterization of a cDNA encoding the 43-kDa membrane-associated inositol-polyphosphate 5-phosphatase

Bird, PI, Chan, BK, Tetaz, T, Mitchell, CA, Laxminarayan, KM

J Biol Chem 1994
15474001 Type II phosphoinositide 5-phosphatases have unique sensitivities towards fatty acid composition and head group phosphorylation

Woscholski, R, Schmid, AC, Nussbaum, R, Mitchell, CA, Wise, HM

FEBS Lett 2004
7721860 Properties of type II inositol polyphosphate 5-phosphatase

Jefferson, AB, Majerus, PW

J Biol Chem 1995
1718960 Cloning and expression of human 75-kDa inositol polyphosphate-5-phosphatase

Ross, TS, Jefferson, AB, Majerus, PW, Mitchell, CA

J Biol Chem 1991
Catalyst Activity

inositol-1,4,5-trisphosphate 5-phosphatase activity of INPP5A/B [plasma membrane]

Orthologous Events
Cross References
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