I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane

Stable Identifier
R-HSA-1855222
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Type I inositol-1,4,5-trisphosphate 5-phosphatase (INPP5A) and the Type II phosphatase (INPP5B) are isoprenylated to the plasma membrane and act as a lipid anchor. Here they dephosphorylate inositol 1,4,5-trisphosphate (I(1,4,5)P3) to inositol 1,4-bisphosphate I(1,4)P2. ).

The following lists the above proteins with their corresponding literature references: INPP5A (Laxminarayan et al. 1994); INPP5B (Jefferson & Majerus 1995, Ross et al. 1991, Schmid et al. 2004).

Literature References
PubMed ID Title Journal Year
15474001 Type II phosphoinositide 5-phosphatases have unique sensitivities towards fatty acid composition and head group phosphorylation

Schmid, AC, Wise, HM, Mitchell, CA, Nussbaum, R, Woscholski, R

FEBS Lett 2004
8006039 Characterization of a cDNA encoding the 43-kDa membrane-associated inositol-polyphosphate 5-phosphatase

Laxminarayan, KM, Chan, BK, Tetaz, T, Bird, PI, Mitchell, CA

J Biol Chem 1994
7721860 Properties of type II inositol polyphosphate 5-phosphatase

Jefferson, AB, Majerus, PW

J Biol Chem 1995
1718960 Cloning and expression of human 75-kDa inositol polyphosphate-5-phosphatase

Ross, TS, Jefferson, AB, Mitchell, CA, Majerus, PW

J Biol Chem 1991
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
inositol-1,4,5-trisphosphate 5-phosphatase activity of INPP5A/B [plasma membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
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Reviewed
Created
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