Reactome | I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol

I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol

Stable Identifier

R-HSA-1855218

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

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I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol

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A group of inositol phosphatases and the broad specificity enzyme inositol-tetrakisphosphate 1-kinase (ITPK1) dephosphorylate inositol 1,3,4,5-tetrakisphosphate (I(1,3,4,5)P4) to inositol 1,3,4-trisphosphate (I(1,3,4)P3). The group of inositol phosphatases involved are: inositol polyphosphate 5-phosphatase OCRL-1 (OCRL), phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 (INPP5D) aka SHIP1, phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 (INPPL1) aka SHIP2, phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (INPP5J) aka PIPP, and synaptic inositol-1,4,5-trisphosphate 5-phosphatase 1 (SYNJ1).

The following lists the above proteins with their corresponding literature references: OCRL (Chang et al. 2002, Zhang et al. 1995, Zhang et al. 1998, Schmid et al. 2004); INPP5D (Drayer et al. 1996, Kavanaugh et al. 1996); INPPL1 (Chi et al. 2004); INPP5J (Mochizuki & Thompson 1999); SYNJ1 (Schmid et al. 2004); ITPK1 (Ho et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
9430698	Cell lines from kidney proximal tubules of a patient with Lowe syndrome lack OCRL inositol polyphosphate 5-phosphatase and accumulate phosphatidylinositol 4,5-bisphosphate Zhang, X, Hartz, PA, Philip, E, Racusen, LC, Majerus, PW	J Biol Chem	1998
8769125	Cloning and expression of a human placenta inositol 1,3,4,5-tetrakisphosphate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase Drayer, AL, Pesesse, X, De Smedt, F, Woscholski, R, Parker, P, Erneux, C	Biochem Biophys Res Commun	1996
7761412	The protein deficient in Lowe syndrome is a phosphatidylinositol-4,5-bisphosphate 5-phosphatase Zhang, X, Jefferson, AB, Auethavekiat, V, Majerus, PW	Proc Natl Acad Sci U S A	1995
8723348	Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2 Kavanaugh, WM, Pot, DA, Chin, SM, Deuter-Reinhard, M, Jefferson, AB, Norris, FA, Masiarz, FR, Cousens, LS, Majerus, PW, Williams, LT	Curr Biol	1996
10593988	Novel inositol polyphosphate 5-phosphatase localizes at membrane ruffles Mochizuki, Y, Takenawa, T	J Biol Chem	1999
15474001	Type II phosphoinositide 5-phosphatases have unique sensitivities towards fatty acid composition and head group phosphorylation Schmid, AC, Wise, HM, Mitchell, CA, Nussbaum, R, Woscholski, R	FEBS Lett	2004
12223481	The human homolog of the rat inositol phosphate multikinase is an inositol 1,3,4,6-tetrakisphosphate 5-kinase Chang, SC, Miller, AL, Feng, Y, Wente, SR, Majerus, PW	J Biol Chem	2002
11909533	Regulation of Ins(3,4,5,6)P(4) signaling by a reversible kinase/phosphatase Ho, MW, Yang, X, Carew, MA, Zhang, T, Hua, L, Kwon, YU, Chung, SK, Adelt, S, Vogel, G, Riley, AM, Potter, BV, Shears, SB	Curr Biol	2002
15316017	Comparative mechanistic and substrate specificity study of inositol polyphosphate 5-phosphatase Schizosaccharomyces pombe Synaptojanin and SHIP2 Chi, Y, Zhou, B, Wang, WQ, Chung, SK, Kwon, YU, Ahn, YH, Chang, YT, Tsujishita, Y, Hurley, JH, Zhang, ZY	J Biol Chem	2004