I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol

Stable Identifier
Reaction [transition]
Homo sapiens
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A group of inositol phosphatases and the broad specificity enzyme inositol-tetrakisphosphate 1-kinase (ITPK1) dephosphorylate inositol 1,3,4,5-tetrakisphosphate (I(1,3,4,5)P4) to inositol 1,3,4-trisphosphate (I(1,3,4)P3). The group of inositol phosphatases involved are: inositol polyphosphate 5-phosphatase OCRL-1 (OCRL), phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 (INPP5D) aka SHIP1, phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 (INPPL1) aka SHIP2, phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (INPP5J) aka PIPP, and synaptic inositol-1,4,5-trisphosphate 5-phosphatase 1 (SYNJ1).

The following lists the above proteins with their corresponding literature references: OCRL (Chang et al. 2002, Zhang et al. 1995, Zhang et al. 1998, Schmid et al. 2004); INPP5D (Drayer et al. 1996, Kavanaugh et al. 1996); INPPL1 (Chi et al. 2004); INPP5J (Mochizuki & Thompson 1999); SYNJ1 (Schmid et al. 2004); ITPK1 (Ho et al. 2002).

Literature References
PubMed ID Title Journal Year
8769125 Cloning and expression of a human placenta inositol 1,3,4,5-tetrakisphosphate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase

Woscholski, R, Parker, P, Pesesse, X, Erneux, C, Drayer, AL, De Smedt, F

Biochem Biophys Res Commun 1996
9430698 Cell lines from kidney proximal tubules of a patient with Lowe syndrome lack OCRL inositol polyphosphate 5-phosphatase and accumulate phosphatidylinositol 4,5-bisphosphate

Majerus, PW, Racusen, LC, Zhang, X, Philip, E, Hartz, PA

J Biol Chem 1998
7761412 The protein deficient in Lowe syndrome is a phosphatidylinositol-4,5-bisphosphate 5-phosphatase

Jefferson, AB, Auethavekiat, V, Majerus, PW, Zhang, X

Proc Natl Acad Sci U S A 1995
8723348 Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2

Kavanaugh, WM, Jefferson, AB, Masiarz, FR, Pot, DA, Majerus, PW, Deuter-Reinhard, M, Chin, SM, Cousens, LS, Norris, FA, Williams, LT

Curr Biol 1996
10593988 Novel inositol polyphosphate 5-phosphatase localizes at membrane ruffles

Takenawa, T, Mochizuki, Y

J Biol Chem 1999
15474001 Type II phosphoinositide 5-phosphatases have unique sensitivities towards fatty acid composition and head group phosphorylation

Woscholski, R, Schmid, AC, Nussbaum, R, Mitchell, CA, Wise, HM

FEBS Lett 2004
12223481 The human homolog of the rat inositol phosphate multikinase is an inositol 1,3,4,6-tetrakisphosphate 5-kinase

Wente, SR, Majerus, PW, Feng, Y, Miller, AL, Chang, SC

J Biol Chem 2002
11909533 Regulation of Ins(3,4,5,6)P(4) signaling by a reversible kinase/phosphatase

Zhang, T, Kwon, YU, Potter, BV, Carew, MA, Chung, SK, Riley, AM, Vogel, G, Hua, L, Ho, MW, Yang, X, Shears, SB, Adelt, S

Curr Biol 2002
15316017 Comparative mechanistic and substrate specificity study of inositol polyphosphate 5-phosphatase Schizosaccharomyces pombe Synaptojanin and SHIP2

Zhou, B, Tsujishita, Y, Hurley, JH, Chi, Y, Kwon, YU, Chung, SK, Zhang, ZY, Chang, YT, Wang, WQ, Ahn, YH

J Biol Chem 2004
Catalyst Activity

inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity of INPP5(3)/ITPK1 [cytosol]

Orthologous Events
Cross References
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