PHLPP dephosphorylates S473 in AKT

Stable Identifier
R-HSA-199425
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The PH domain leucine-rich repeat-containing protein phosphatases, PHLPP1 (Gao et al. 2005) and PHLPP2 (Brognard et al. 2007) can specifically dephosphorylate the serine residue and inactivate AKT.

Literature References
Participants
Participates
Event Information
Catalyst Activity

protein serine/threonine phosphatase activity of PHLPP (Mn2+ cofactor) [cytosol]

Orthologous Events
Authored
Reviewed
Created
Cite Us!