PHLPP dephosphorylates S473 in AKT

Stable Identifier
R-HSA-199425
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The PH domain leucine-rich repeat-containing protein phosphatases, PHLPP1 (Gao et al. 2005) and PHLPP2 (Brognard et al. 2007) can specifically dephosphorylate the serine residue and inactivate AKT.

Literature References
Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine phosphatase activity of PHLPP (Mn2+ cofactor) [cytosol]
Physical Entity
Activity
Orthologous Events
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Created