PTPN1 dephosphorylates PTK6

Stable Identifier
R-HSA-8849435
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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PTPN1 dephosphorylates PTK6
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Protein tyrosine phosphatase PTPN1 (PTP1B) dephosphorylates tyrosine residue Y342 of PTK6 (BRK), resulting in PTK6 inactivation (Fan et al. 2013).
Literature References
PubMed ID Title Journal Year
23814047 Protein-tyrosine phosphatase 1B antagonized signaling by insulin-like growth factor-1 receptor and kinase BRK/PTK6 in ovarian cancer cells

Fan, G, Tonks, NK, Lin, G, Lucito, R

J. Biol. Chem. 2013
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Output
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Catalyst Activity

protein tyrosine phosphatase activity of p-Y342-PTK6:PTPN1 [cytosol]

Physical Entity
p-Y342-PTK6:PTPN1 [cytosol] (Homo sapiens)
Activity
protein tyrosine phosphatase activity (GO:0004725)
Orthologous Events
PTPN1 dephosphorylates PTK6 (Bos taurus)
PTPN1 dephosphorylates PTK6 (Mus musculus)
PTPN1 dephosphorylates PTK6 (Rattus norvegicus)
PTPN1 dephosphorylates PTK6 (Sus scrofa)
PTPN1 dephosphorylates PTK6 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2016-01-05)
Reviewed
Pires, IM  (2016-02-07)
Created
Orlic-Milacic, M  (2015-12-15)
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