PTPN1 dephosphorylates PTK6

Stable Identifier
R-HSA-8849435
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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PTPN1 dephosphorylates PTK6
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Protein tyrosine phosphatase PTPN1 (PTP1B) dephosphorylates tyrosine residue Y342 of PTK6 (BRK), resulting in PTK6 inactivation (Fan et al. 2013).

Literature References
PubMed ID Title Journal Year
23814047 Protein-tyrosine phosphatase 1B antagonized signaling by insulin-like growth factor-1 receptor and kinase BRK/PTK6 in ovarian cancer cells

Fan, G, Tonks, NK, Lin, G, Lucito, R

J. Biol. Chem. 2013
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Output
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as an event of
Catalyst Activity

protein tyrosine phosphatase activity of p-Y342-PTK6:PTPN1 [cytosol]

Physical Entity
p-Y342-PTK6:PTPN1 [cytosol] (Homo sapiens)
Activity
protein tyrosine phosphatase activity (GO:0004725)
Orthologous Events
PTPN1 dephosphorylates PTK6 (Bos taurus)
PTPN1 dephosphorylates PTK6 (Danio rerio)
PTPN1 dephosphorylates PTK6 (Mus musculus)
PTPN1 dephosphorylates PTK6 (Rattus norvegicus)
PTPN1 dephosphorylates PTK6 (Sus scrofa)
PTPN1 dephosphorylates PTK6 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2016-01-05)
Reviewed
Pires, IM  (2016-02-07)
Created
Orlic-Milacic, M  (2015-12-15)
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