PTPN1 dephosphorylates PTK6

Stable Identifier
R-HSA-8849435
Type
Reaction
Species
Homo sapiens
Compartment
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Protein tyrosine phosphatase PTPN1 (PTP1B) dephosphorylates tyrosine residue Y342 of PTK6 (BRK), resulting in PTK6 inactivation (Fan et al. 2013).

Literature References
PubMed ID Title Journal Year
23814047 Protein-tyrosine phosphatase 1B antagonized signaling by insulin-like growth factor-1 receptor and kinase BRK/PTK6 in ovarian cancer cells

Fan, G, Tonks, NK, Lin, G, Lucito, R

J. Biol. Chem. 2013
Participants
Participates
Catalyst Activity

protein tyrosine phosphatase activity of p-Y342-PTK6:PTPN1 [cytosol]

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