tRNA:XPOT:RAN:GTP translocates from the nucleus to the cytosol

Stable Identifier
R-HSA-6783483
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The nuclear export receptor XPOT (Exportin-t) interacts with both tRNA (Li and Sprinzl 2006) and RAN:GTP and the complex is translocated from the nucleus to the cytosol through the nuclear pore (Arts et al. 1998, Kutay et al. 1998, Kuersten et al. 2002, reviewed in Leisegang et al. 2012). RAN:GTP-dependent interactions of XPOT with components of the nuclear pore may increase the efficiency of the transport cycle (Kuersten et al. 2002).

Literature References
PubMed ID Title Journal Year
22944664 Exportin t and Exportin 5: tRNA and miRNA biogenesis - and beyond

Leisegang, MS, Martin, R, Ramírez, AS, Bohnsack, MT

Biol. Chem. 2012
9660920 Identification of a tRNA-specific nuclear export receptor

Kutay, U, Lipowsky, G, Izaurralde, E, Bischoff, FR, Schwarzmaier, P, Hartmann, E, Görlich, D

Mol. Cell 1998
17224653 Interaction of immobilized human exportin-t with calf liver tRNA

Li, S, Sprinzl, M

RNA Biol 2006
12138183 Steady-state nuclear localization of exportin-t involves RanGTP binding and two distinct nuclear pore complex interaction domains

Kuersten, S, Arts, GJ, Walther, TC, Englmeier, L, Mattaj, IW

Mol. Cell. Biol. 2002
9512417 Identification of a nuclear export receptor for tRNA

Arts, GJ, Fornerod, M, Mattaj, IW

Curr. Biol. 1998
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Catalyst Activity
Title
structural constituent of nuclear pore activity of Nuclear Pore Complex (NPC) [nuclear envelope]
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