I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol

Stable Identifier
Reaction [transition]
Homo sapiens
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A group of inositol phosphatases dephosphorylate inositol 1,4,5-trisphosphate (I(1,4,5)P3) to inositol 1,4-bisphosphate (I(1,4)P2). The group of inositol phosphatases involved are: inositol polyphosphate 5-phosphatase OCRL-1 (OCRL), phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (INPP5J), and synaptic inositol-1,4,5-trisphosphate 5-phosphatase 1 (SYNJ1).

The following lists the above proteins with their corresponding literature references: OCRL (Zhang et al. 1995, Zhang et al. 1998, Schmid et al. 2004); INPP5J (Mochizuki & Thompson 1999); SYNJ1 (Schmid et al. 2004).

Literature References
PubMed ID Title Journal Year
9430698 Cell lines from kidney proximal tubules of a patient with Lowe syndrome lack OCRL inositol polyphosphate 5-phosphatase and accumulate phosphatidylinositol 4,5-bisphosphate

Majerus, PW, Racusen, LC, Zhang, X, Philip, E, Hartz, PA

J Biol Chem 1998
7761412 The protein deficient in Lowe syndrome is a phosphatidylinositol-4,5-bisphosphate 5-phosphatase

Jefferson, AB, Auethavekiat, V, Majerus, PW, Zhang, X

Proc Natl Acad Sci U S A 1995
10593988 Novel inositol polyphosphate 5-phosphatase localizes at membrane ruffles

Takenawa, T, Mochizuki, Y

J Biol Chem 1999
15474001 Type II phosphoinositide 5-phosphatases have unique sensitivities towards fatty acid composition and head group phosphorylation

Woscholski, R, Schmid, AC, Nussbaum, R, Mitchell, CA, Wise, HM

FEBS Lett 2004
Catalyst Activity

inositol-1,4,5-trisphosphate 5-phosphatase activity of INPP5(4) [cytosol]

Orthologous Events
Cross References
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