I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol

Stable Identifier
R-HSA-1855174
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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A group of inositol phosphatases dephosphorylate inositol 1,4,5-trisphosphate (I(1,4,5)P3) to inositol 1,4-bisphosphate (I(1,4)P2). The group of inositol phosphatases involved are: inositol polyphosphate 5-phosphatase OCRL-1 (OCRL), phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (INPP5J), and synaptic inositol-1,4,5-trisphosphate 5-phosphatase 1 (SYNJ1).

The following lists the above proteins with their corresponding literature references: OCRL (Zhang et al. 1995, Zhang et al. 1998, Schmid et al. 2004); INPP5J (Mochizuki & Thompson 1999); SYNJ1 (Schmid et al. 2004).

Literature References
PubMed ID Title Journal Year
7761412 The protein deficient in Lowe syndrome is a phosphatidylinositol-4,5-bisphosphate 5-phosphatase

Zhang, X, Jefferson, AB, Auethavekiat, V, Majerus, PW

Proc Natl Acad Sci U S A 1995
9430698 Cell lines from kidney proximal tubules of a patient with Lowe syndrome lack OCRL inositol polyphosphate 5-phosphatase and accumulate phosphatidylinositol 4,5-bisphosphate

Zhang, X, Hartz, PA, Philip, E, Racusen, LC, Majerus, PW

J Biol Chem 1998
10593988 Novel inositol polyphosphate 5-phosphatase localizes at membrane ruffles

Mochizuki, Y, Takenawa, T

J Biol Chem 1999
15474001 Type II phosphoinositide 5-phosphatases have unique sensitivities towards fatty acid composition and head group phosphorylation

Schmid, AC, Wise, HM, Mitchell, CA, Nussbaum, R, Woscholski, R

FEBS Lett 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
inositol-1,4,5-trisphosphate 5-phosphatase activity of INPP5(4) [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
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