Hydrolysis of Ran:GTP to Ran:GDP

Stable Identifier
R-HSA-165055
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
cytosol, nuclear envelope
ReviewStatus
5/5
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Hydrolysis of Ran:GTP to Ran:GDP
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Ran-GAP, a Ran-specific GTPase-activating protein converts Ran-GTP to Ran-GDP, producing a Ran-GTP gradient across the nuclear membrane.
Literature References
PubMed ID Title Journal Year
7878053 Human RanGTPase-activating protein RanGAP1 is a homologue of yeast Rna1p involved in mRNA processing and transport

Bischoff, FR, Ponstingl, H, Kempf, T, Krebber, H, Hermes, I

Proc Natl Acad Sci U S A 1995
Participants
Input
Output
Participates
as an event of
Catalyst Activity

GTPase activity of Rev multimer-bound HIV-1 mRNA:Crm1:Ran:GTP [cytosol]

Physical Entity
Rev multimer-bound HIV-1 mRNA:Crm1:Ran:GTP [cytosol] (Homo sapiens)
Activity
GTPase activity (GO:0003924)
This event is regulated
Positively by
Regulator
RANGAP1 [nuclear envelope] (Homo sapiens)
Regulator
RANBP1 [nuclear envelope] (Homo sapiens)
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease DOID:526 HIV infection
Authored
Matthews, L  (2005-07-27)
Rice, AP  (2005-07-27)
Reviewed
Kumar, A  (2007-02-01)
Created
Matthews, L  (2005-07-27)
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