SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol

Stable Identifier
R-HSA-2872498
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The microsomal Na+/(PO4)3- transporter isoform 1 (SLC17A3, NPT4 isoform 1) is a member of the anion-cation symporter family. It is expressed in liver, kidney and intestine and may function as a cotransporter of sodium (Na+) and phosphate ((PO4)3- or Pi) across the ER membrane (Melis et al. 2004).

Literature References
PubMed ID Title Journal Year
15505377 NPT4, a new microsomal phosphate transporter: mutation analysis in glycogen storage disease type Ic

Melis, D, Havelaar, AC, Verbeek, E, Smit, GP, Benedetti, A, Mancini, GM, Verheijen, F

J. Inherit. Metab. Dis. 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
sodium:phosphate symporter activity of SLC17A3 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
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