Reactome | PI3P is dephosphorylated to PI by MTMR2:SBF1

PI3P is dephosphorylated to PI by MTMR2:SBF1

Stable Identifier

R-HSA-6809777

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

PI3P is dephosphorylated to PI by MTMR2:SBF1

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Binding to SBF1 (MTMR5) increases phosphatidylinositol-3-phosphatase catalytic activity of MTMR2 (Kim et al. 2003). SBF1 promotes perinuclear localization of MTMR2 (Kim et al. 2003), presumably to the endoplasmic reticulum (ER) membrane, as both proteins can localize to the ER membrane (Berger et al. 2003, Li et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
25522275	SBF-1 exerts strong anticervical cancer effect through inducing endoplasmic reticulum stress-associated cell death via targeting sarco/endoplasmic reticulum Ca(2+)-ATPase 2 Li, W, Ouyang, Z, Zhang, Q, Wang, L, Shen, Y, Wu, X, Wu, X, Gu, Y, Shu, Y, Yu, B, Sun, Y, Xu, Q	Cell Death Dis	2014
14530412	Membrane association of myotubularin-related protein 2 is mediated by a pleckstrin homology-GRAM domain and a coiled-coil dimerization module Berger, P, Schaffitzel, C, Berger, I, Ban, N, Suter, U	Proc. Natl. Acad. Sci. U.S.A.	2003
12668758	Regulation of myotubularin-related (MTMR)2 phosphatidylinositol phosphatase by MTMR5, a catalytically inactive phosphatase Kim, SA, Vacratsis, PO, Firestein, R, Cleary, ML, Dixon, JE	Proc. Natl. Acad. Sci. U.S.A.	2003