Reactome | PP2A dephosphorylates serine-127 of YAP1

PP2A dephosphorylates serine-127 of YAP1

Stable Identifier

R-HSA-9865226

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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PP2A dephosphorylates serine-127 of YAP1

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Interaction between integrin alpha5 (ITGA5) and fibronectin acts through an uncharacterized mechanism to cause protein phosphatase PP2A to dephosphorylate serine-127 of YAP1 (Yun et al. 2019, Jiang et al. 2021). Phosphoserine-127 causes YAP1 to be retained in the cytosol and its dephosphorylation allows YAP1 to transit to the nucleus.

Literature References

PubMed ID	Title	Journal	Year
34055807	Protein Phosphatase 2A Mediates YAP Activation in Endothelial Cells Upon VEGF Stimulation and Matrix Stiffness Di Matteo, M, Ruiz de Almodóvar, C, Mazzone, M, Cafarello, ST, Wang, X, Hu, J, Dong, X, Jiang, X, Wu, Z, Adler, H, Shen, Y	Front Cell Dev Biol	2021
31408443	Integrin α5β1 regulates PP2A complex assembly through PDE4D in atherosclerosis Zhuang, Z, Yun, S, Pallas, DC, Hu, R, Schwaemmle, ME, Scherer, AN, Koleske, AJ, Schwartz, MA	J Clin Invest	2019