IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]

Stable Identifier
R-HSA-111524
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
inosine 5'-monophosphate + L-aspartate + GTP => adenylosuccinate + guanosine 5'-diphosphate + orthophosphate
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Two isoforms of adenylosuccinate synthetase, ADSS and ADSSL1, catalyze the reaction of IMP, aspartate, and GTP to form adenylosuccinate, GDP, and orthophosphate (Powell et al. 1992; Sun et al. 2005). ADSS is a homotetramer (unpublished crystallographic data - PDB 2V40) and ADSSL1 is inferred to be a tetramer likewise.

Literature References
PubMed ID Title Journal Year
1592113 Cloning and characterization of the cDNA encoding human adenylosuccinate synthetase

Powell, SM, Zalkin, H, Dixon, JE

FEBS Lett 1992
15786719 Molecular cloning and characterization of a novel muscle adenylosuccinate synthetase, AdSSL1, from human bone marrow stromal cells

Sun, H, Li, N, Wang, X, Chen, T, Shi, L, Zhang, L, Wang, J, Wan, T, Cao, X

Mol Cell Biochem 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
adenylosuccinate synthase activity of ADSS, ADSSL1 dimers [cytosol]
Physical Entity
Activity
This event is regulated
Orthologous Events
Cross References
Rhea
Authored
Created