IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]

Stable Identifier
R-HSA-111524
Type
Reaction
Species
Homo sapiens
Compartment
cytosol
Synonyms
inosine 5'-monophosphate + L-aspartate + GTP => adenylosuccinate + guanosine 5'-diphosphate + orthophosphate
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IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Two isoforms of adenylosuccinate synthetase, ADSS and ADSSL1, catalyze the reaction of IMP, aspartate, and GTP to form adenylosuccinate, GDP, and orthophosphate (Powell et al. 1992; Sun et al. 2005). ADSS is a homotetramer (unpublished crystallographic data - PDB 2V40) and ADSSL1 is inferred to be a tetramer likewise.

Literature References
PubMed ID Title Journal Year
15786719 Molecular cloning and characterization of a novel muscle adenylosuccinate synthetase, AdSSL1, from human bone marrow stromal cells

Wan, T, Li, N, Wang, J, Wang, X, Chen, T, Zhang, L, Sun, H, Cao, X, Shi, L

Mol Cell Biochem 2005
1592113 Cloning and characterization of the cDNA encoding human adenylosuccinate synthetase

Zalkin, H, Powell, SM, Dixon, JE

FEBS Lett 1992
Participants
Input
Output
Participates
as an event of
Catalyst Activity

adenylosuccinate synthase activity of ADSS, ADSSL1 dimers [cytosol]

Physical Entity
ADSS, ADSSL1 dimers [cytosol] (Homo sapiens)
Activity
adenylosuccinate synthase activity (GO:0004019)
This event is regulated
Negatively by
Regulator
GDP [cytosol]
Regulator
F1,6PP [cytosol]
Regulator
ADS [cytosol]
Regulator
GMP [cytosol]
Orthologous Events
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Bos taurus)
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Caenorhabditis elegans)
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Canis familiaris)
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Danio rerio)
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Dictyostelium discoideum)
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Drosophila melanogaster)
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Gallus gallus)
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Mus musculus)
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Plasmodium falciparum)
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Rattus norvegicus)
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Saccharomyces cerevisiae)
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Schizosaccharomyces pombe)
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Sus scrofa)
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Xenopus tropicalis)
Cross References
Rhea
Authored
D'Eustachio, P  (2004-02-19)
Created
D'Eustachio, P  (2004-02-18)
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