Reactome | IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]

IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]

Stable Identifier

R-HSA-111524

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

inosine 5'-monophosphate + L-aspartate + GTP => adenylosuccinate + guanosine 5'-diphosphate + orthophosphate

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IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]

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Two isoforms of adenylosuccinate synthetase, ADSS and ADSSL1, catalyze the reaction of IMP, aspartate, and GTP to form adenylosuccinate, GDP, and orthophosphate (Powell et al. 1992; Sun et al. 2005). ADSS is a homotetramer (unpublished crystallographic data - PDB 2V40) and ADSSL1 is inferred to be a tetramer likewise.

Literature References

PubMed ID	Title	Journal	Year
1592113	Cloning and characterization of the cDNA encoding human adenylosuccinate synthetase Powell, SM, Zalkin, H, Dixon, JE	FEBS Lett	1992
15786719	Molecular cloning and characterization of a novel muscle adenylosuccinate synthetase, AdSSL1, from human bone marrow stromal cells Sun, H, Li, N, Wang, X, Chen, T, Shi, L, Zhang, L, Wang, J, Wan, T, Cao, X	Mol Cell Biochem	2005