ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region

Stable Identifier
Reaction [transition]
Homo sapiens
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Some members of the ABC transporter superfamily are able to mediate the efflux of a broad range of cytotoxic drugs from cells, leading to the name multidrug resistance (MDR) proteins (Seeger and van Veen 2009). The ABCB1 (P-glycoprotein 1[PGP], multidrug resistance protein 1 [MRP1]) is the most characterised MDR (Shen et al. 1986, Gottesman & Pastan 1988). ABCB5 (Frank et al. 2005) and ABCA8 (Tsuruoka et al. 2002) are newer members of MDRs.

Literature References
PubMed ID Title Journal Year
12379217 Functional analysis of ABCA8, a new drug transporter

Tsuruoka, S, Ishibashi, K, Yamamoto, H, Wakaumi, M, Suzuki, M, Schwartz, GJ, Imai, M, Fujimura, A

Biochem Biophys Res Commun 2002
15899824 ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma

Frank, NY, Margaryan, A, Huang, Y, Schatton, T, Waaga-Gasser, AM, Gasser, M, Sayegh, MH, Sadee, W, Frank, MH

Cancer Res 2005
3457471 Human multidrug-resistant cell lines: increased mdr1 expression can precede gene amplification

Shen, DW, Fojo, A, Chin, JE, Roninson, IB, Richert, N, Pastan, I, Gottesman, MM

Science 1986
Catalyst Activity

ATPase-coupled transmembrane transporter activity of ABCA8/B1/B5 [plasma membrane]

Orthologous Events
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