Reactome | DARPP-32 is dephosphorylated on Thr75 by PP2A

DARPP-32 is dephosphorylated on Thr75 by PP2A

Stable Identifier

R-HSA-201790

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Opioid Signalling (Homo sapiens)
        
        DARPP-32 events (Homo sapiens)
        
        DARPP-32 is dephosphorylated on Thr75 by PP2A (Homo sapiens)

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DARPP-32 is dephosphorylated on Thr75 by PP2A

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PP2A is ubiquitously expressed in eukaryotic cells, existing as a heterotrimeric enzyme composed of a 36-kDa catalytic C subunit, a 64-kDa scaffolding A subunit, and multiple regulatory B subunits. The B subunits are thought to influence enzyme activity, substrate specificity, and subcellular localization. PKA phosphorylates PP2A thereby activating the enzyme and is responsible for dopamine/cAMP-dependent dephosphorylation of Thr-75 of DARPP-32.

Literature References

PubMed ID	Title	Journal	Year
12065642	Regulation of DARPP-32 dephosphorylation at PKA- and Cdk5-sites by NMDA and AMPA receptors: distinct roles of calcineurin and protein phosphatase-2A Bibb, JA, Greengard, P, Matsuyama, S, Hamada, M, Higashi, H, Nairn, AC, Nishi, A	J Neurochem	2002
17535922	The B''/PR72 subunit mediates Ca2+-dependent dephosphorylation of DARPP-32 by protein phosphatase 2A Sung, JY, McAvoy, T, Ahn, JH, Janssens, V, Greengard, P, Nairn, AC, Goris, J, Nishi, A	Proc Natl Acad Sci U S A	2007