(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol

Stable Identifier
Reaction [transition]
Homo sapiens
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Diphosphoinositol polyphosphate phosphohydrolases (DIPP), also known as nucleoside diphosphate-linked moiety X motif (NUDT) proteins, dephosphorylate inositol bisdiphospho-tetrakisphosphate ((PP)2-IP4) to inositol diphospho-pentakisphosphate (PP-IP5). The NUDT proteins involved are: nucleoside diphosphate-linked moiety X motif 3 (NUDT3), 4 (NUDT4), 10 (NUDT10), and 11 (NUDT11). The reactants consumed are: inositol 1,5-bisdiphospho-2,3,4,6-tetrakisphosphate (1,5-(PP)2-IP4) and inositol 3,5-bisdiphospho-1,2,4,6-tetrakisphosphate (3,5-(PP)2-IP4). The products made are: inositol 1-diphospho-2,3,4,5,6-pentakisphosphate (1-PP-IP5) and 3-diphospho-1,2,4,5,6-pentakisphosphate (3-PP-IP5).

The following lists the above proteins with their corresponding literature references: NUDT3 (Safrany et al. 1999, Safrany et al. 1998, Yang et al. 1999, Caffrey et al. 2000), NUDT4 (Caffrey et al. 2000), NUDT10 (Leslie et al. 2002, Hidaka et al. 2002) and NUDT11 (Leslie et al. 2002, Hidaka et al. 2002).
Literature References
PubMed ID Title Journal Year
10585413 Site-directed mutagenesis of diphosphoinositol polyphosphate phosphohydrolase, a dual specificity NUDT enzyme that attacks diadenosine polyphosphates and diphosphoinositol polyphosphates

Safrany, ST, Yang, X, Shears, SB

J Biol Chem 1999
10419486 The diadenosine hexaphosphate hydrolases from Schizosaccharomyces pombe and Saccharomyces cerevisiae are homologues of the human diphosphoinositol polyphosphate phosphohydrolase. Overlapping substrate specificities in a MutT-type protein

Barnes, LD, Safrany, ST, Falck, JR, Ingram, SW, Cartwright, JL, Shears, SB, McLennan, AG

J Biol Chem 1999
12121577 Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases

Safrany, ST, Leslie, NR, McLennan, AG

BMC Biochem 2002
12105228 An adjacent pair of human NUDT genes on chromosome X are preferentially expressed in testis and encode two new isoforms of diphosphoinositol polyphosphate phosphohydrolase

Barnes, LD, Nickel, GC, Zhang, T, Hidaka, K, Falck, JR, Caffrey, JJ, Hua, L, Shears, SB, Carrel, L

J Biol Chem 2002
10777568 Discovery of molecular and catalytic diversity among human diphosphoinositol-polyphosphate phosphohydrolases. An expanding Nudt family

Safrany, ST, Caffrey, JJ, Yang, X, Shears, SB

J Biol Chem 2000
9822604 A novel context for the 'MutT' module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolase

Safrany, ST, Caffrey, JJ, Bembenek, ME, Burkhart, WA, Yang, X, Shears, SB, Moyer, MB

EMBO J 1998
Catalyst Activity

inositol bisdiphosphate tetrakisphosphate diphosphatase activity of NUDT(1) [cytosol]

Orthologous Events
Cross References
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