Cap-bound mRNA is activated by helicases

Stable Identifier
R-HSA-72647
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Cap-bound mRNA is activated by helicases
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The DEAD-box RNA helicase eIF4A, together with the RNA-binding proteins eIF4B or eIF4H, is thought to unwind RNA secondary structures near the 5'-end of the mRNA and in the presence of ATP.
Literature References
PubMed ID Title Journal Year
6853548 New initiation factor activity required for globin mRNA translation.

Tahara, SM, Morgan, MA, Grifo, JA, Merrick, WC, Shatkin, AJ

J Biol Chem 1983
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Catalyst Activity

RNA helicase activity of eIF4A subunits complex [cytosol]

Physical Entity
eIF4A subunits complex [cytosol] (Homo sapiens)
Activity
RNA helicase activity (GO:0003724)
Orthologous Events
Cap-bound mRNA is activated by helicases (Canis familiaris)
Cap-bound mRNA is activated by helicases (Mus musculus)
Cap-bound mRNA is activated by helicases (Plasmodium falciparum)
Cap-bound mRNA is activated by helicases (Saccharomyces cerevisiae)
Cap-bound mRNA is activated by helicases (Schizosaccharomyces pombe)
Created
Merrick, WC  (2002-12-16)
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