Reactome | PPP1CC dephosphorylates PLK1

PPP1CC dephosphorylates PLK1

Stable Identifier

R-HSA-9853385

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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PP1gamma (PPP1CC), a kinetochore component, dephosphorylates PLK1 at threonine residue T210 in a time-dependent manner. PPP1CC-mediated dephosphorylation of p-T210-PLK1 is attenuated by binding of FIRMM (also known as Apolo1 or FLIP) to PPP1CC (Xu et al. 2021).

Literature References

PubMed ID	Title	Journal	Year
34260926	Feedback control of PLK1 by Apolo1 ensures accurate chromosome segregation Sun, B, Tian, R, Poser, I, Garba, F, Li, L, Liu, X, Green, H, Chu, L, Ge, Y, Dou, Z, Lu, J, Pan, W, Yuan, X, Liu, D, Wang, D, Mullen, M, Duan, W, Duan, H, Ali, M, Hyman, A, Yao, X, Xu, L	Cell Rep	2021