Reactome | ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3

ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3

Stable Identifier

R-HSA-9753278

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane, extracellular region

ReviewStatus

5/5

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ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3

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Excretion of glucuronidated acetaminophen (APAP-GlcA) and sulfated acetaminophen (APAP-SO3) into bile involves the ATP-binding cassette sub-family C member 2 transporter (ABCC2) and the broad substrate specificity ATP-binding cassette transporter (ABCG2), both found in the canalicular membrane of hepatocytes where they secrete drug conjugates into bile (Giacomini et al. 2010, Kidron et al. 2012, review McGill & Jaeschke 2013).

Literature References

PubMed ID	Title	Journal	Year
20190787	Membrane transporters in drug development Giacomini, KM, Huang, SM, Tweedie, DJ, Benet, LZ, Brouwer, KL, Chu, X, Dahlin, A, Evers, R, Fischer, V, Hillgren, KM, Hoffmaster, KA, Ishikawa, T, Keppler, D, Kim, RB, Lee, CA, Niemi, M, Polli, JW, Sugiyama, Y, Swaan, PW, Ware, JA, Wright, SH, Yee, SW, Zamek-Gliszczynski, MJ, Zhang, L	Nat Rev Drug Discov	2010
22406294	Impact of probe compound in MRP2 vesicular transport assays Kidron, H, Wissel, G, Manevski, N, Häkli, M, Ketola, RA, Finel, M, Yliperttula, M, Xhaard, H, Urtti, A	Eur J Pharm Sci	2012