Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E:Cofactor C-> Beta-tubulin:GDP :alpha-tubulin:GTP heterodimer +Cofactor E+ Cofactor D+ Cofactor C+ Pi

Stable Identifier
R-BTA-391533
Type
Reaction [dissociation]
Species
Bos taurus
Compartment
General
SVG |   | PPTX  | SBGN
Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E:Cofactor C-> Beta-tubulin:GDP :alpha-tubulin:GTP heterodimer +Cofactor E+ Cofactor D+ Cofactor C+ Pi

Beta tubulin within the active (Factor E:alpha tubulin: Factor D:beta tubulin:Factor C )-supercomplex hydrolyzes GTP. This results in the dissociation of the complex and the release of the native tubulin heterodimer (Tian et al., 1997).

Literature References
PubMed ID Title Journal Year
9265649 Tubulin subunits exist in an activated conformational state generated and maintained by protein cofactors

Tian, G, Lewis, SA, Feierbach, B, Stearns, T, Rommelaere, H, Ampe, C, Cowan, NJ

J Cell Biol 1997
Participants
Orthologous Events
Authored
Reviewed
Created
Cite Us!