The heat shock protein Hsc70 and auxilin, a J-domain containing protein, are responsible for clathrin disassembly through an ATP-dependent reaction. This uncoating step may be a point in the pathway subject to regulation. This final step releases the vesicle from the clathrin cage. The vesicle still contatins a specific Vamp molecule, part of the targeting and fusion mechanism that delivers the vesicle to its ultimate destination. This vesicle also contains its cargo, membrane proteins embeded in the Golgi-associated vesicle membrane.
James, DE, Bryant, NJ, Govers, R
Acton, SL, Jackson, AP, Brodsky, FM, Parham, P, Wong, DH
Zhang, F, Eisenberg, E, Greene, LE, Zhao, X, Lee, DW
Lilley, KS, Borner, GH, Hester, S, Robinson, MS, Harbour, M
Holstein, SE, Eisenberg, E, Greene, LE, Martin, B, Lindner, R, Ungewickell, H, Ungewickell, E, Barouch, W, Prasad, K
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