NAPRT1 dimer transfers PRIB to NCA to form NAMN

Stable Identifier
R-HSA-197186
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
A phosphoribosyl group is added to nicotinate to form nicotinate mononucleotide (NaMN)
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Cytosolic nicotinate phosphoribosyltransferase (NaPRT) catalyzes the Mg++-dependent reaction of nicotinate and phosphoribosyl pyrophosphate to form nicotinate mononucleotide (NaMN, nicotinate D-ribonucleotide) and pyrophosphate. The active form of the enzyme is a homodimer (Preiss and Handler 1958; Niedel and Dietrich 1973; Hara et al. 2007).

Literature References
PubMed ID Title Journal Year
17604275 Elevation of cellular NAD levels by nicotinic acid and involvement of nicotinic acid phosphoribosyltransferase in human cells

Hara, N, Yamada, K, Shibata, T, Osago, H, Hashimoto, T, Tsuchiya, M

J Biol Chem 2007
4349867 Nicotinate phosphoribosyltransferase of human erythrocytes. Purification and properties.

Niedel, J, Dietrich, LS

J Biol Chem 1973
13563527 Biosynthesis of diphosphopyridine nucleotide. II. Enzymatic aspects.

Preiss, J, Handler, P

J Biol Chem 1958
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
nicotinate phosphoribosyltransferase activity of NAPRT1 dimer [cytosol]
Physical Entity
Activity
This event is regulated
Orthologous Events
Cross References
Rhea
Authored
Created