Reactome | NAPRT1 dimer transfers PRIB to NCA to form NAMN

NAPRT1 dimer transfers PRIB to NCA to form NAMN

Stable Identifier

R-HSA-197186

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

A phosphoribosyl group is added to nicotinate to form nicotinate mononucleotide (NaMN)

ReviewStatus

5/5

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NAPRT1 dimer transfers PRIB to NCA to form NAMN

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Cytosolic nicotinate phosphoribosyltransferase (NaPRT) catalyzes the Mg++-dependent reaction of nicotinate and phosphoribosyl pyrophosphate to form nicotinate mononucleotide (NaMN, nicotinate D-ribonucleotide) and pyrophosphate. The active form of the enzyme is a homodimer (Preiss and Handler 1958; Niedel and Dietrich 1973; Hara et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
4349867	Nicotinate phosphoribosyltransferase of human erythrocytes. Purification and properties. Dietrich, LS, Niedel, J	J Biol Chem	1973
17604275	Elevation of cellular NAD levels by nicotinic acid and involvement of nicotinic acid phosphoribosyltransferase in human cells Shibata, T, Osago, H, Hara, N, Tsuchiya, M, Hashimoto, T, Yamada, K	J Biol Chem	2007
13563527	Biosynthesis of diphosphopyridine nucleotide. II. Enzymatic aspects. Handler, P, Preiss, J	J Biol Chem	1958