PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane

Stable Identifier
R-HSA-1676114
Type
Reaction
Species
Homo sapiens
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At the Golgi membrane, phosphatidylinositide phosphatase SAC1 (SACM1L) dephosphorylates phosphatidylinositol 3-phosphate (PI3P) to phosphatidylinositol (PI) but not as efficiently as phosphatidylinositol 4-phosphate (PI4P) dephosphorylation. No significant activity of this enzyme towards phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) was detected (Rohde et al. 2003).

Literature References
PubMed ID Title Journal Year
14527956 The human phosphatidylinositol phosphatase SAC1 interacts with the coatomer I complex

Paiha, K, Konrad, G, Rohde, HM, Boehmelt, G, Cheong, FY, Mayinger, P

J Biol Chem 2003
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Catalyst Activity

phosphatidylinositol-3-phosphatase activity of SACM1L [Golgi membrane]

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