PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane

Stable Identifier
R-HSA-1676114
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Golgi membrane, cytosol
ReviewStatus
5/5
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PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane
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At the Golgi membrane, phosphatidylinositide phosphatase SAC1 (SACM1L) dephosphorylates phosphatidylinositol 3-phosphate (PI3P) to phosphatidylinositol (PI) but not as efficiently as phosphatidylinositol 4-phosphate (PI4P) dephosphorylation. No significant activity of this enzyme towards phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) was detected (Rohde et al. 2003).

Literature References
PubMed ID Title Journal Year
14527956 The human phosphatidylinositol phosphatase SAC1 interacts with the coatomer I complex

Paiha, K, Konrad, G, Rohde, HM, Boehmelt, G, Cheong, FY, Mayinger, P

J Biol Chem 2003
Participants
Input
Output
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as an event of
Catalyst Activity

phosphatidylinositol-3-phosphatase activity of SACM1L [Golgi membrane]

Physical Entity
SACM1L [Golgi membrane] (Homo sapiens)
Activity
phosphatidylinositol-3-phosphatase activity (GO:0004438)
Orthologous Events
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Bos taurus)
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Caenorhabditis elegans)
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Canis familiaris)
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Danio rerio)
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Dictyostelium discoideum)
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Drosophila melanogaster)
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Gallus gallus)
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Mus musculus)
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Plasmodium falciparum)
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Rattus norvegicus)
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Saccharomyces cerevisiae)
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Schizosaccharomyces pombe)
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Sus scrofa)
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Xenopus tropicalis)
Cross References
Rhea
Authored
Williams, MG  (2011-10-18)
Reviewed
Wakelam, M  (2012-05-14)
Created
Williams, MG  (2011-10-17)
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