Reactome | ABCB6 transports porphyrin from cytosol to mitchondrial matrix

ABCB6 transports porphyrin from cytosol to mitchondrial matrix

Stable Identifier

R-HSA-1369065

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial outer membrane, cytosol, mitochondrial matrix

Synonyms

MTABC3 transports porphyrin into mitochondria

ReviewStatus

5/5

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ABCB6 transports porphyrin from cytosol to mitchondrial matrix

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The human gene ABCB6 encodes a mitochondrial half-type ATP-binding cassette (ABC) protein MTABC3 which is uniquely located on the outer mitochondrial membrane and is functional as a homodimer (Krishnamurthy et al. 2006). It plays a crucial role in heme synthesis by mediating porphyrin uptake into mitochondria (Mitsuhashi et al. 2000, Krishnamurthy et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
10837493	MTABC3, a novel mitochondrial ATP-binding cassette protein involved in iron homeostasis Nakajima, N, Yokoi, N, Mitsuhashi, N, Seino, S, Yano, H, Iwanaga, T, Shibata, T, Yokoyama, Y, Miki, T, Miyazaki, M, Senbongi, H	J Biol Chem	2000
17006453	Identification of a mammalian mitochondrial porphyrin transporter Sosa-Pineda, B, Sampath, J, Fukuda, Y, Sun, D, Murti, KG, Krishnamurthy, PC, Du, G, Schuetz, JD, Wang, J, Mercer, KE	Nature	2006