Hydrolysis of ATP and release of tubulin folding intermediate from CCT/TriC

Stable Identifier
R-HSA-389954
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Hydrolysis of ATP and release of tubulin folding intermediate from CCT/TriC
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Group II chaperonins enclose substrate proteins following substrate binding through the formation of a "built- in" lid over the central cavity. Upon ATP binding, lid formation is triggered by the transition state of ATP hydrolysis (Meyer, et al., 2003). In the case of CCT-mediated tubulin folding, one or more rounds of ATP hydrolysis are likely required before the association of non-exchangeable GTP with chaperonin-bound alpha tubulin.
Participants
Input
Output
Participates
as an event of
Inferred From
Hydrolysis of ATP and release of tubulin folding intermediate from CCT/TriC (Mus musculus)
Authored
Matthews, L  (2008-12-01)
Reviewed
Cowan, NJ  (2009-01-21)
Created
Matthews, L  (2009-01-22)
Cite Us!