ATP Hydrolysis By Myosin

Stable Identifier
R-HSA-390593
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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ATP Hydrolysis By Myosin
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The cleft closes like a clam shell around the ATP molecule, triggering a large shape change that causes the myosin head to release actin and be displaced along the actin filament by a distance of about 5 nm. Hydrolysis of ATP occurs, but the ADP remains tightly bound to the protein.
Literature References
PubMed ID Title Journal Year
10747208 Regulation of contraction in striated muscle

Gordon, AM, Homsher, E, Regnier, M

Physiol Rev 2000
  Regulatory Mechanisms of Striated Muscle Contraction

Ohtsuki, I, Ebashi, S

  2007
Participants
Input
Output
Participates
as an event of
Catalyst Activity

myosin phosphatase activity of Myosin Complex [cytosol]

Physical Entity
Myosin Complex [cytosol] (Homo sapiens)
Activity
myosin phosphatase activity (GO:0017018)
Orthologous Events
ATP Hydrolysis By Myosin (Bos taurus)
ATP Hydrolysis By Myosin (Canis familiaris)
ATP Hydrolysis By Myosin (Gallus gallus)
ATP Hydrolysis By Myosin (Mus musculus)
ATP Hydrolysis By Myosin (Rattus norvegicus)
ATP Hydrolysis By Myosin (Sus scrofa)
Authored
Gillespie, ME  (2003-07-01)
Reviewed
Rush, MG  (2008-01-11)
Created
Gillespie, ME  (2009-02-10)
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