Reactome | ATP Hydrolysis By Myosin

ATP Hydrolysis By Myosin

Stable Identifier

R-HSA-390593

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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The cleft closes like a clam shell around the ATP molecule, triggering a large shape change that causes the myosin head to release actin and be displaced along the actin filament by a distance of about 5 nm. Hydrolysis of ATP occurs, but the ADP remains tightly bound to the protein.

Literature References

PubMed ID	Title	Journal	Year
10747208	Regulation of contraction in striated muscle Gordon, AM, Homsher, E, Regnier, M	Physiol Rev	2000
	Regulatory Mechanisms of Striated Muscle Contraction Ohtsuki, I, Ebashi, S		2007