ATP Hydrolysis By Myosin

Stable Identifier
R-HSA-390593
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The cleft closes like a clam shell around the ATP molecule, triggering a large shape change that causes the myosin head to release actin and be displaced along the actin filament by a distance of about 5 nm. Hydrolysis of ATP occurs, but the ADP remains tightly bound to the protein.

Literature References
PubMed ID Title Journal Year
  Regulatory Mechanisms of Striated Muscle Contraction

Ebashi, S, Ohtsuki, I

  2007
10747208 Regulation of contraction in striated muscle

Gordon, AM, Homsher, E, Regnier, M

Physiol Rev 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
myosin phosphatase activity of Myosin Complex [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created