PTPN3 dephosphorylates MAPK12

Stable Identifier
R-HSA-8867658
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

PTPN3-mediated dephosphorylation of MAPK12 promotes RAS signaling and transformation through an unknown mechanism (Tang et al, 2005; Hou et al, 2010; Chen et al, 2014). Consistent with a role for dephosphorylated MAPK12 and PTPN3 in promoting RAS signaling, depletion of PTPN3 or MAPK12 inhibits malignant growth in RAS-activated human cancer cell lines and in mouse models. In addition, RAS signaling increases protein levels of both MAPK12 and PTPN3, suggesting the presence of a positive feedback loop (Hou et al, 2010). Dephosphorylation of MAPK12 may promote its incorporation into complexes with ERK proteins, though the functional significance of this is unclear (Tang et al, 2005).

Literature References
PubMed ID Title Journal Year
25314968 Reciprocal allosteric regulation of p38γ and PTPN3 involves a PDZ domain-modulated complex formation

Chen, KE, Lin, SY, Wu, MJ, Ho, MR, Santhanam, A, Chou, CC, Meng, TC, Wang, AH

Sci Signal 2014
15851477 Essential role of p38gamma in K-Ras transformation independent of phosphorylation

Tang, J, Qi, X, Mercola, D, Han, J, Chen, G

J. Biol. Chem. 2005
20332238 PTPH1 dephosphorylates and cooperates with p38gamma MAPK to increase ras oncogenesis through PDZ-mediated interaction

Hou, SW, Zhi, HY, Pohl, N, Loesch, M, Qi, XM, Li, RS, Basir, Z, Chen, G

Cancer Res. 2010
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine phosphatase activity of PTPN3:p-T183,Y185-MAPK12 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
Cite Us!