Inhibition of SGG results in the dephosphorylation of the 'destruction complex' by PP2A and release of ARM

Stable Identifier
R-DME-209112
Type
Reaction [transition]
Species
Drosophila melanogaster
Compartment
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The binding of Dishevelled (DSH) to Axin (AXN) in the 'destruction complex' appears to inhibit the kinase Shaggy (SGG). As this component appears to be the main instigator in keeping the 'destruction complex' phosphorylated, it's inactivation means the protein phosphatase orthologue, PP2A, can dephosphorylate members of the 'destruction complex'. This results in a decreased binding affinity for Armadillo (ARM) by AXN and APC (APC/APC2). The now unphosphorylated ARM disassociates from the 'destruction complex' into the cytoplasm.

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Catalyst Activity
Catalyst Activity
Title
protein serine/threonine phosphatase activity of PP2A [cytosol]
Physical Entity
Activity
Inferred From
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Created