CARNS1 transforms ATP, L-His, b-Ala to CARN

Stable Identifier
R-HSA-6786245
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
ATP + beta-alanine + L-histidine => ADP + carnosine + H(+) + phosphate
ReviewStatus
5/5
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CARNS1 transforms ATP, L-His, b-Ala to CARN
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Carnosine (beta-alanyl-L-histidine) and homocarnosine (gamma-aminobutyryl-L-histidine) are abundant dipeptides in skeletal muscle and brain of most vertebrates. Carnosine synthase 1 (CARNS1) transforms ATP, L-histidine (L-His) and beta-alanine (b-Ala) to carnosine (CARN) with much greater efficiency than synthesis of homocarnosine (Drozak et al. 2010).
Literature References
PubMed ID Title Journal Year
20097752 Molecular identification of carnosine synthase as ATP-grasp domain-containing protein 1 (ATPGD1)

Drozak, J, Veiga-da-Cunha, M, Vertommen, D, Stroobant, V, Van Schaftingen, E

J. Biol. Chem. 2010
Participants
Input
Output
Participates
as an event of
Catalyst Activity

carnosine synthase activity of CARNS1 [cytosol]

Physical Entity
CARNS1 [cytosol] (Homo sapiens)
Activity
carnosine synthase activity (GO:0047730)
Orthologous Events
CARNS1 transforms ATP, L-His, b-Ala to CARN (Bos taurus)
CARNS1 transforms ATP, L-His, b-Ala to CARN (Canis familiaris)
CARNS1 transforms ATP, L-His, b-Ala to CARN (Gallus gallus)
CARNS1 transforms ATP, L-His, b-Ala to CARN (Mus musculus)
CARNS1 transforms ATP, L-His, b-Ala to CARN (Rattus norvegicus)
CARNS1 transforms ATP, L-His, b-Ala to CARN (Sus scrofa)
CARNS1 transforms ATP, L-His, b-Ala to CARN (Xenopus tropicalis)
Cross References
RHEA
Authored
Jassal, B  (2015-07-06)
Reviewed
D'Eustachio, P  (2015-09-14)
D'Eustachio, P  (2024-11-08)
Created
Jassal, B  (2015-07-06)
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