Atp2b2 (PMCA2) transports Ca2+ from the cytosol to the extracellular region

Stable Identifier
R-MMU-9668464
Type
Reaction [transition]
Species
Mus musculus
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Atp2b2 (PMCA2) transports Ca2+ from the cytosol to the extracellular region
Atp2b2 (wa isoform) is located in the plasma membrane of stereocilia bundles of inner hair cells and outer hair cells and transports calcium ions from the cytosol to the extracellular region with concomitant hydrolysis of ATP (Wood et al. 2004, Spiden et al. 2008, Bortolozzi et al. 2010). Atp2b2 appears to facilitate an efflux of calcium ions that enter the stereocilia during depolarization caused by the opening of the mechanoelectrical transduction channel, hence Atp2b2 plays a role in repolarization of the cell (Spiden et al. 2008, Bortolozzi et al. 2010).
Literature References
PubMed ID Title Journal Year
15357414 Low endolymph calcium concentrations in deafwaddler2J mice suggest that PMCA2 contributes to endolymph calcium maintenance

Wood, JD, Muchinsky, SJ, Filoteo, AG, Penniston, JT, Tempel, BL

J. Assoc. Res. Otolaryngol. 2004
20826782 The novel PMCA2 pump mutation Tommy impairs cytosolic calcium clearance in hair cells and links to deafness in mice

Bortolozzi, M, Brini, M, Parkinson, N, Crispino, G, Scimemi, P, De Siati, RD, Di Leva, F, Parker, A, Ortolano, S, Arslan, E, Brown, SD, Carafoli, E, Mammano, F

J. Biol. Chem. 2010
18974863 The novel mouse mutation Oblivion inactivates the PMCA2 pump and causes progressive hearing loss

Spiden, SL, Bortolozzi, M, Di Leva, F, De Angelis, MH, Fuchs, H, Lim, D, Ortolano, S, Ingham, NJ, Brini, M, Carafoli, E, Mammano, F, Steel, KP

PLoS Genet. 2008
Participants
Input
Output
Catalyst Activity

P-type calcium transporter activity of Atp2b2 [plasma membrane]

Physical Entity
Atp2b2 [plasma membrane] (Mus musculus)
Activity
P-type calcium transporter activity (GO:0005388)
Orthologous Events
ATP2B2-wa (PMCA2-wa) transports Ca2+ from the cytosol to the extracellular region (Homo sapiens)
Authored
May, B  (2019-11-26)
Reviewed
Dallos, P  (2020-09-14)
Furness, DN  (2020-09-14)
Created
May, B  (2019-11-26)
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