abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate

Stable Identifier
R-MMU-2161526
Type
Reaction [transition]
Species
Mus musculus
Compartment
cytosol, extracellular region, plasma membrane
Synonyms
Abcb1-mediated abacavir efflux
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate
The Abcb1a transporter associated with the plasma membrane mediates the ATP-dependent efflux of abacavir (Shaik et al. 2007).
Literature References
PubMed ID Title Journal Year
17709369 P-glycoprotein-mediated active efflux of the anti-HIV1 nucleoside abacavir limits cellular accumulation and brain distribution

Giri, N, Elmquist, WF, Pan, G, Shaik, N

Drug Metab Dispos 2007
Participants
Input
Output
Catalyst Activity

ATPase-coupled transmembrane transporter activity of Abcb1a [plasma membrane]

Physical Entity
Abcb1a [plasma membrane] (Mus musculus)
Activity
ATPase-coupled transmembrane transporter activity (GO:0042626)
Orthologous Events
abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate (Homo sapiens)
Authored
D'Eustachio, P  (2012-03-14)
Reviewed
Jassal, B  (2012-03-16)
Created
D'Eustachio, P  (2012-03-14)
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