Reactome | ABCC1,ABCG2 transport C18-S1P to extracellular region

ABCC1,ABCG2 transport C18-S1P to extracellular region

Stable Identifier

R-HSA-9843721

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane, extracellular region

ReviewStatus

5/5

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ABCC1,ABCG2 transport C18-S1P to extracellular region

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The proton pumps ABCC1, ABCG2 transport sphing-4-enine 1-phosphate (sphingosine-1-phosphate, C18-S1P) out of cells. ABCC1 is mainly expressed in mast cells, fibroblasts, and endothelial cells (Mitra et al., 2006; Nieuwenhuis et al., 2009). Export of C18-S1P by ABCG2 has been shown in MCF-7 epithelial cells (Takabe et al., 2010). These processes support a role of C18-S1P secretion in mast cell migration, cytoprotection, maintenance of epithelial barriers, and cancer/multidrug resistance (reviewed by Reitsema et al., 2014).

Literature References

PubMed ID	Title	Journal	Year
19370318	Involvement of the ABC-transporter ABCC1 and the sphingosine 1-phosphate receptor subtype S1P(3) in the cytoprotection of human fibroblasts by the glucocorticoid dexamethasone Nieuwenhuis, B, Lüth, A, Chun, J, Huwiler, A, Pfeilschifter, J, Schäfer-Korting, M, Kleuser, B	J Mol Med (Berl)	2009
	Sphingosine-1-phosphate transport and its role in immunology Reitsema, V, Bouma, H, Kok, JW
17050692	Role of ABCC1 in export of sphingosine-1-phosphate from mast cells Mitra, P, Oskeritzian, CA, Payne, SG, Beaven, MA, Milstien, S, Spiegel, S	Proc Natl Acad Sci U S A	2006
20110355	Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2 Takabe, K, Kim, RH, Allegood, JC, Mitra, P, Ramachandran, S, Nagahashi, M, Harikumar, KB, Hait, NC, Milstien, S, Spiegel, S	J Biol Chem	2010