Reactome | ABCG5:ABCG8 transports sterols from cytosol to extracellular region

ABCG5:ABCG8 transports sterols from cytosol to extracellular region

Stable Identifier

R-HSA-265783

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

Synonyms

ABCG5:ABCG8-mediated export of cholesterol and phytosterols, sterols[cytosol] + ATP => sterols[extracellular] + ADP + Pi

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

ABCG5:ABCG8 transports sterols from cytosol to extracellular region

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The complex of ATP-binding cassette sub-family G members 5 and 8 (ABCG5:ABCG8) in the plasma membrane mediates the ATP-dependent export of cytosolic sterols (cholesterol and phytosterols). Mutations affecting the ABCG5/8 proteins are associated with the accumulation of high levels of cholesterol and phytosterols in the body, demonstrating the specificity and physiological importance of this process (Berge et al. 2000). Human ABCG5/8 has not been studied in detail, but the homologous mouse protein complex mediate ATP-dependent sterol export (Wang et al. 2006). The mouse proteins localize to the apical plasma membranes of enterocytes and hepatocytes, consistent with the hypothesis that in vivo ABCG5/8 mediates sterol export into the gut lumen and from hepatocytes into the bile (Graf et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
11099417	Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters Berge, KE, Tian, H, Graf, GA, Yu, L, Grishin, NV, Schultz, J, Kwiterovich, P, Shan, B, Barnes, R, Hobbs, HH	Science	2000