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About
What is Reactome ?
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Privacy Notice
Disclaimer
Digital Preservation
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Table of Contents
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COVID-19 Disease Pathways
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ADP [nucleoplasm]
Stable Identifier
R-ALL-113582
Type
Chemical Compound [SimpleEntity]
Compartment
nucleoplasm
Synonyms
Adenosine 5'-diphosphate, ADP(3-)
Icon
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Cell Cycle (Bos taurus)
Cell Cycle Checkpoints (Bos taurus)
G1/S DNA Damage Checkpoints (Bos taurus)
p53-Dependent G1/S DNA damage checkpoint (Bos taurus)
p53-Dependent G1 DNA Damage Response (Bos taurus)
Stabilization of p53 (Bos taurus)
ATM phosphorylates MDM2 (Bos taurus)
ADP [nucleoplasm]
ATM phosphorylates TP53 at S15 (Bos taurus)
ADP [nucleoplasm]
Autodegradation of the E3 ubiquitin ligase COP1 (Bos taurus)
Phosphorylation of COP1 at Ser-387 by ATM (Bos taurus)
ADP [nucleoplasm]
CHEK2 phosphorylates TP53 (Bos taurus)
ADP [nucleoplasm]
p53-Independent G1/S DNA damage checkpoint (Bos taurus)
p53-Independent DNA Damage Response (Bos taurus)
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A (Bos taurus)
Phosphorylation of Cdc25A at Ser-123 by Chk2 (Bos taurus)
ADP [nucleoplasm]
G2/M Checkpoints (Bos taurus)
Activation of ATR in response to replication stress (Bos taurus)
Activation of claspin (Bos taurus)
ADP [nucleoplasm]
G2/M DNA damage checkpoint (Bos taurus)
ATR phosphorylates TP53 (Bos taurus)
ADP [nucleoplasm]
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex (Bos taurus)
Phosphorylation of Cdc25C at Ser216 by CHEK2 (Bos taurus)
ADP [nucleoplasm]
Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Bos taurus)
ADP [nucleoplasm]
Phosphorylation and activation of CHEK2 by ATM (Bos taurus)
ADP [nucleoplasm]
p-T68-CHEK2 autophosphorylates (Bos taurus)
ADP [nucleoplasm]
G2/M DNA replication checkpoint (Bos taurus)
Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Bos taurus)
ADP [nucleoplasm]
Cell Cycle, Mitotic (Bos taurus)
M Phase (Bos taurus)
Mitotic Metaphase and Anaphase (Bos taurus)
Mitotic Metaphase/Anaphase Transition (Bos taurus)
Down Regulation of Emi1 through Phosphorylation of Emi1 (Bos taurus)
ADP [nucleoplasm]
Mitotic Prophase (Bos taurus)
CCNB1:p-T160-CDK1 phosphorylates NUMA1 (Bos taurus)
ADP [nucleoplasm]
Condensation of Prophase Chromosomes (Bos taurus)
CDK1 phosphorylates PHF8 (Bos taurus)
ADP [nucleoplasm]
CDK1 phosphorylates condensin II subunit NCAPD3 (Bos taurus)
ADP [nucleoplasm]
PLK1 hyperphosphorylates Condensin II complex (Bos taurus)
ADP [nucleoplasm]
MASTL Facilitates Mitotic Progression (Bos taurus)
MASTL (GWL) phosphorylates ARPP19 (Bos taurus)
ADP [nucleoplasm]
MASTL phosphorylates ENSA (Bos taurus)
ADP [nucleoplasm]
Nuclear Envelope Breakdown (Bos taurus)
Depolymerization of the Nuclear Lamina (Bos taurus)
CDK1 phosphorylates LPIN (Bos taurus)
ADP [nucleoplasm]
CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Bos taurus)
ADP [nucleoplasm]
Depolymerization of lamin filaments after PKC-mediated phosphorylation (Bos taurus)
ADP [nucleoplasm]
VRK1/VRK2 phosphorylate BANF1 (Bos taurus)
ADP [nucleoplasm]
Mitotic Telophase/Cytokinesis (Bos taurus)
Regulation of KIF20A (MKL2) by phosphorylation (Bos taurus)
ADP [nucleoplasm]
Regulation of KIF23 (MKLP1) by phosphorylation (Bos taurus)
ADP [nucleoplasm]
Mitotic G1 phase and G1/S transition (Bos taurus)
G0 and Early G1 (Bos taurus)
Phosphorylation of LIN52 component of MuvB by DYRK1A (Bos taurus)
ADP [nucleoplasm]
G1 Phase (Bos taurus)
Cyclin D associated events in G1 (Bos taurus)
CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Bos taurus)
ADP [nucleoplasm]
Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Bos taurus)
ADP [nucleoplasm]
Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Bos taurus)
ADP [nucleoplasm]
Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Bos taurus)
ADP [nucleoplasm]
G1/S Transition (Bos taurus)
Activation of the pre-replicative complex (Bos taurus)
Mcm2-7 is phosphorylated by DDK (Bos taurus)
ADP [nucleoplasm]
Cyclin E associated events during G1/S transition (Bos taurus)
CAK-mediated phosphorylation of Cyclin E:Cdk2 (Bos taurus)
ADP [nucleoplasm]
Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Bos taurus)
ADP [nucleoplasm]
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes (Bos taurus)
Cyclin E:CDK2-mediated phosphorylation of RB1 (Bos taurus)
ADP [nucleoplasm]
SCF(Skp2)-mediated degradation of p27/p21 (Bos taurus)
Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21 (Bos taurus)
ADP [nucleoplasm]
Mitotic G2-G2/M phases (Bos taurus)
G2 Phase (Bos taurus)
Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Bos taurus)
ADP [nucleoplasm]
G2/M Transition (Bos taurus)
Cyclin A/B1/B2 associated events during G2/M transition (Bos taurus)
CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Bos taurus)
ADP [nucleoplasm]
CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes (Bos taurus)
ADP [nucleoplasm]
CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 (Bos taurus)
ADP [nucleoplasm]
Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Bos taurus)
ADP [nucleoplasm]
Polo-like kinase mediated events (Bos taurus)
Inactivation of Myt1 kinase (Bos taurus)
ADP [nucleoplasm]
Inactivation of Wee1 kinase (Bos taurus)
ADP [nucleoplasm]
PLK1 phosphorylates FOXM1 (Bos taurus)
ADP [nucleoplasm]
Regulation of mitotic cell cycle (Bos taurus)
APC/C-mediated degradation of cell cycle proteins (Bos taurus)
Regulation of APC/C activators between G1/S and early anaphase (Bos taurus)
Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Bos taurus)
ADP [nucleoplasm]
Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Bos taurus)
ADP [nucleoplasm]
Phosphorylation of Emi1 (Bos taurus)
Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Bos taurus)
ADP [nucleoplasm]
Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Bos taurus)
ADP [nucleoplasm]
S Phase (Bos taurus)
Cyclin A:Cdk2-associated events at S phase entry (Bos taurus)
CAK-mediated phosphorylation of Cyclin A:Cdk2 (Bos taurus)
ADP [nucleoplasm]
Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Bos taurus)
ADP [nucleoplasm]
Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Bos taurus)
ADP [nucleoplasm]
Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Bos taurus)
ADP [nucleoplasm]
SCF(Skp2)-mediated degradation of p27/p21 (Bos taurus)
Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21 (Bos taurus)
ADP [nucleoplasm]
Synthesis of DNA (Bos taurus)
DNA strand elongation (Bos taurus)
Lagging Strand Synthesis (Bos taurus)
Polymerase switching (Bos taurus)
Loading of PCNA - Sliding Clamp Formation (Bos taurus)
ADP [nucleoplasm]
Leading Strand Synthesis (Bos taurus)
Polymerase switching (Bos taurus)
Loading of PCNA - Sliding Clamp Formation (Bos taurus)
ADP [nucleoplasm]
Switching of origins to a post-replicative state (Bos taurus)
CDK-mediated phosphorylation and removal of Cdc6 (Bos taurus)
Cdc6 protein is phosphorylated by CDK (Bos taurus)
ADP [nucleoplasm]
Orc1 removal from chromatin (Bos taurus)
Orc1 is phosphorylated by cyclin A/CDK2 (Bos taurus)
ADP [nucleoplasm]
Chromosome Maintenance (Bos taurus)
Telomere Maintenance (Bos taurus)
Extension of Telomeres (Bos taurus)
Telomere C-strand (Lagging Strand) Synthesis (Bos taurus)
Polymerase switching on the C-strand of the telomere (Bos taurus)
Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Bos taurus)
ADP [nucleoplasm]
Processive synthesis on the C-strand of the telomere (Bos taurus)
Formation of the Flap Intermediate on the C-strand (Bos taurus)
ADP [nucleoplasm]
Telomere Extension By Telomerase (Bos taurus)
CDK2:CCNA phosphorylates TERF2 (Bos taurus)
ADP [nucleoplasm]
Disassociation of Telomerase RNP and the Chromosome End (Bos taurus)
ADP [nucleoplasm]
Cellular responses to stimuli (Bos taurus)
Cellular responses to stress (Bos taurus)
Cellular Senescence (Bos taurus)
DNA Damage/Telomere Stress Induced Senescence (Bos taurus)
ATM phosphorylates TP53 at S15 (Bos taurus)
ADP [nucleoplasm]
MRN activates ATM (Bos taurus)
ADP [nucleoplasm]
MRN bound to shortened telomeres activates ATM (Bos taurus)
ADP [nucleoplasm]
Oncogene Induced Senescence (Bos taurus)
MAPKs phosphorylate ETS1 and ETS2 (Bos taurus)
ADP [nucleoplasm]
Oxidative Stress Induced Senescence (Bos taurus)
Activated JNKs phosphorylate c-JUN (Bos taurus)
ADP [nucleoplasm]
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Bos taurus)
ADP [nucleoplasm]
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 (Bos taurus)
ADP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Bos taurus)
ADP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK5 (Bos taurus)
ADP [nucleoplasm]
MAPKAPK5 phosphorylates TP53 (Bos taurus)
ADP [nucleoplasm]
c-FOS activation by phospho ERK1/2 (Bos taurus)
ADP [nucleoplasm]
p-MAPKAPK3 phosphorylates BMI1 (Bos taurus)
ADP [nucleoplasm]
Senescence-Associated Secretory Phenotype (SASP) (Bos taurus)
CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Bos taurus)
ADP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Bos taurus)
ADP [nucleoplasm]
MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Bos taurus)
ADP [nucleoplasm]
Cellular response to chemical stress (Bos taurus)
KEAP1-NFE2L2 pathway (Bos taurus)
Nuclear events mediated by NFE2L2 (Bos taurus)
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Bos taurus)
GSK3B phosphorylates p-NFE2L2 (Bos taurus)
ADP [nucleoplasm]
PRKAA2 phosphorylates nuclear NFE2L2 (Bos taurus)
ADP [nucleoplasm]
Cellular response to heat stress (Bos taurus)
HSF1-dependent transactivation (Bos taurus)
Phosphorylation of HSF1 at Ser230 induces transactivation (Bos taurus)
ADP [nucleoplasm]
Phosphorylation of HSF1 at Ser326 induces transactivation (Bos taurus)
ADP [nucleoplasm]
Regulation of HSF1-mediated heat shock response (Bos taurus)
HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Bos taurus)
HSP70s:ADP [nucleoplasm] (Bos taurus)
HSPA12A:ADP [nucleoplasm] (Bos taurus)
ADP [nucleoplasm]
HSPA12B:ADP [nucleoplasm] (Bos taurus)
ADP [nucleoplasm]
HSPA13:ADP [nucleoplasm] (Bos taurus)
ADP [nucleoplasm]
HSPA14:ADP [nucleoplasm] (Bos taurus)
ADP [nucleoplasm]
HSPA1A:ADP [nucleoplasm] (Bos taurus)
ADP [nucleoplasm]
HSPA1L:ADP [nucleoplasm] (Bos taurus)
ADP [nucleoplasm]
HSPA2:ADP [nucleoplasm] (Bos taurus)
ADP [nucleoplasm]
HSPA4:ADP [nucleoplasm] (Bos taurus)
ADP [nucleoplasm]
HSPA4L:ADP [nucleoplasm] (Bos taurus)
ADP [nucleoplasm]
HSPA5:ADP [nucleoplasm] (Bos taurus)
ADP [nucleoplasm]
HSPA6:ADP [nucleoplasm] (Bos taurus)
ADP [nucleoplasm]
HSPA8:ADP [nucleoplasm] (Bos taurus)
ADP [nucleoplasm]
HSPA9:ADP [nucleoplasm] (Bos taurus)
ADP [nucleoplasm]
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Bos taurus)
ATP hydrolysis by HSP90 (Bos taurus)
ADP [nucleoplasm]
DNA Repair (Bos taurus)
DNA Damage Bypass (Bos taurus)
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Bos taurus)
Translesion Synthesis by POLH (Bos taurus)
SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Bos taurus)
ADP [nucleoplasm]
DNA Double-Strand Break Repair (Bos taurus)
DNA Double Strand Break Response (Bos taurus)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Bos taurus)
ATM phosphorylates EYA1-4 (Bos taurus)
ADP [nucleoplasm]
ATM phosphorylates HERC2 (Bos taurus)
ADP [nucleoplasm]
ATM phosphorylates MDC1 (Bos taurus)
ADP [nucleoplasm]
ATM phosphorylates NBN (Bos taurus)
ADP [nucleoplasm]
ATM phosphorylates TP53 at S15 (Bos taurus)
ADP [nucleoplasm]
ATM phosphorylates TP53BP1 at DNA DSBs (Bos taurus)
ADP [nucleoplasm]
ATM phosphorylates WHSC1 (Bos taurus)
ADP [nucleoplasm]
ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Bos taurus)
ADP [nucleoplasm]
Activated ATM phosphorylates ABL1 (Bos taurus)
ADP [nucleoplasm]
CHEK2 phosphorylates BRCA1 (Bos taurus)
ADP [nucleoplasm]
Phosphorylation and activation of CHEK2 by ATM (Bos taurus)
ADP [nucleoplasm]
Phosphorylation of BRCA1-A complex at multiple sites by ATM (Bos taurus)
ADP [nucleoplasm]
WICH phosphorylates H2AFX on Y142 (Bos taurus)
ADP [nucleoplasm]
p-T68-CHEK2 autophosphorylates (Bos taurus)
ADP [nucleoplasm]
Sensing of DNA Double Strand Breaks (Bos taurus)
MRN activates ATM (Bos taurus)
ADP [nucleoplasm]
Homology Directed Repair (Bos taurus)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Bos taurus)
HDR through Single Strand Annealing (SSA) (Bos taurus)
ABL1 phosphorylates RAD52 (Bos taurus)
ADP [nucleoplasm]
Processing of DNA double-strand break ends (Bos taurus)
ATM phosphorylates RBBP8 (Bos taurus)
ADP [nucleoplasm]
ATR phosphorylates RPA2 (Bos taurus)
ADP [nucleoplasm]
CDK2 phosphorylates RBBP8 (Bos taurus)
ADP [nucleoplasm]
Nonhomologous End-Joining (NHEJ) (Bos taurus)
Activated ATM phosphorylates DCLRE1C (Bos taurus)
ADP [nucleoplasm]
DNA-PKcs autophosphorylates (Bos taurus)
ADP [nucleoplasm]
PRKDC phosphorylates DCLRE1C at DNA DSBs (Bos taurus)
ADP [nucleoplasm]
Fanconi Anemia Pathway (Bos taurus)
ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Bos taurus)
ADP [nucleoplasm]
Mismatch Repair (Bos taurus)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (Bos taurus)
Formation of MSH2:MSH3 Complex (Bos taurus)
ADP [nucleoplasm]
MSH2:MSH3:ADP [nucleoplasm] (Bos taurus)
ADP [nucleoplasm]
MSH2:MSH3 binds insertion/deletion loop of 2 bases or more (Bos taurus)
MSH2:MSH3:ADP [nucleoplasm] (Bos taurus)
ADP [nucleoplasm]
MSH2:MSH3:ADP:DNA containing IDL of 2 bases or more [nucleoplasm] (Bos taurus)
MSH2:MSH3:ADP [nucleoplasm] (Bos taurus)
ADP [nucleoplasm]
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (Bos taurus)
Formation of MSH2:MSH6 Complex (Bos taurus)
ADP [nucleoplasm]
MSH2:MSH6:ADP [nucleoplasm] (Bos taurus)
ADP [nucleoplasm]
MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Bos taurus)
MSH2:MSH6:ADP [nucleoplasm] (Bos taurus)
ADP [nucleoplasm]
MSH2:MSH6:ADP:DNA containing 1-2 base mismatch [nucleoplasm] (Bos taurus)
MSH2:MSH6:ADP [nucleoplasm] (Bos taurus)
ADP [nucleoplasm]
MSH2:MSH6 exchanges ADP for ATP (Bos taurus)
ADP [nucleoplasm]
MSH2:MSH6:ADP:DNA containing 1-2 base mismatch [nucleoplasm] (Bos taurus)
MSH2:MSH6:ADP [nucleoplasm] (Bos taurus)
ADP [nucleoplasm]
Nucleotide Excision Repair (Bos taurus)
Global Genome Nucleotide Excision Repair (GG-NER) (Bos taurus)
Formation of Incision Complex in GG-NER (Bos taurus)
ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Bos taurus)
ADP [nucleoplasm]
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Bos taurus)
Dual incision in TC-NER (Bos taurus)
ERCC2-facilitated RNA Pol II backtracking in TC-NER (Bos taurus)
ADP [nucleoplasm]
ERCC3-facilitated RNA Pol II backtracking in TC-NER (Bos taurus)
ADP [nucleoplasm]
DNA Replication (Bos taurus)
DNA Replication Pre-Initiation (Bos taurus)
Activation of the pre-replicative complex (Bos taurus)
Mcm2-7 is phosphorylated by DDK (Bos taurus)
ADP [nucleoplasm]
Synthesis of DNA (Bos taurus)
DNA strand elongation (Bos taurus)
Lagging Strand Synthesis (Bos taurus)
Polymerase switching (Bos taurus)
Loading of PCNA - Sliding Clamp Formation (Bos taurus)
ADP [nucleoplasm]
Leading Strand Synthesis (Bos taurus)
Polymerase switching (Bos taurus)
Loading of PCNA - Sliding Clamp Formation (Bos taurus)
ADP [nucleoplasm]
Switching of origins to a post-replicative state (Bos taurus)
CDK-mediated phosphorylation and removal of Cdc6 (Bos taurus)
Cdc6 protein is phosphorylated by CDK (Bos taurus)
ADP [nucleoplasm]
Orc1 removal from chromatin (Bos taurus)
Orc1 is phosphorylated by cyclin A/CDK2 (Bos taurus)
ADP [nucleoplasm]
Developmental Biology (Bos taurus)
MITF-M-regulated melanocyte development (Bos taurus)
MITF-M-dependent gene expression (Bos taurus)
Regulation of MITF-M-dependent genes involved in pigmentation (Bos taurus)
USF1 is phosphorylated by p-MAPK14 (Bos taurus)
ADP [nucleoplasm]
Transcriptional and post-translational regulation of MITF-M expression and activity (Bos taurus)
AKT3 phosphorylates TBX3 (Bos taurus)
ADP [nucleoplasm]
GSK3B phosphorylates p-S409 MITF-M at S397, S401 and S405 (Bos taurus)
ADP [nucleoplasm]
GSK3B phosphorylates p-S73 MITF-M at residue S69 (Bos taurus)
ADP [nucleoplasm]
MAPK1 phosphorylates SOX10 (Bos taurus)
ADP [nucleoplasm]
MAPK1-dependent phosphorylation of MITF-M (Bos taurus)
ADP [nucleoplasm]
RPS6KA1-dependent phosphorylation of MITF-M (Bos taurus)
ADP [nucleoplasm]
Myogenesis (Bos taurus)
Phosphorylation of MEF2 proteins by p38 (Bos taurus)
ADP [nucleoplasm]
Nervous system development (Bos taurus)
Axon guidance (Bos taurus)
NCAM signaling for neurite out-growth (Bos taurus)
ERK1/2 phosphorylates MSK1 (Bos taurus)
ADP [nucleoplasm]
MSK1 activates CREB (Bos taurus)
ADP [nucleoplasm]
Gene expression (Transcription) (Bos taurus)
Epigenetic regulation of gene expression (Bos taurus)
Epigenetic regulation by WDR5-containing histone modifying complexes (Bos taurus)
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes (Bos taurus)
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes (Bos taurus)
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis (Bos taurus)
ABL1 phosphorylates PPARG2 (Bos taurus)
ADP [nucleoplasm]
RNA Polymerase I Transcription (Bos taurus)
RNA Polymerase I Promoter Clearance (Bos taurus)
RNA Polymerase I Promoter Opening (Bos taurus)
Phosphorylation of UBF-1:rDNA Promoter (Bos taurus)
ADP [nucleoplasm]
RNA Polymerase II Transcription (Bos taurus)
Generic Transcription Pathway (Bos taurus)
Transcriptional Regulation by MECP2 (Bos taurus)
Regulation of MECP2 expression and activity (Bos taurus)
HIPK2 phosphorylates MECP2 (Bos taurus)
ADP [nucleoplasm]
Transcriptional Regulation by TP53 (Bos taurus)
Regulation of TP53 Activity (Bos taurus)
Regulation of TP53 Activity through Acetylation (Bos taurus)
PI5P Regulates TP53 Acetylation (Bos taurus)
MAP2K6 phosphorylates PIP4K2B (Bos taurus)
ADP [nucleoplasm]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Bos taurus)
ADP [nucleoplasm]
Regulation of TP53 Activity through Methylation (Bos taurus)
ATM phosphorylates TTC5 (Bos taurus)
ADP [nucleoplasm]
CHEK2 phosphorylates TTC5 (Bos taurus)
ADP [nucleoplasm]
Regulation of TP53 Activity through Phosphorylation (Bos taurus)
AMPK phosphorylates TP53 (Bos taurus)
ADP [nucleoplasm]
ATM phosphorylates DYRK2 (Bos taurus)
ADP [nucleoplasm]
ATM phosphorylates TP53 at S15 (Bos taurus)
ADP [nucleoplasm]
ATR phosphorylates TP53 (Bos taurus)
ADP [nucleoplasm]
AURKA phosphorylates TP53 (Bos taurus)
ADP [nucleoplasm]
AURKB phosphorylates TP53 (Bos taurus)
ADP [nucleoplasm]
CDK2 phosphorylates TP53 (Bos taurus)
ADP [nucleoplasm]
CDK5 phosphorylates TP53 (Bos taurus)
ADP [nucleoplasm]
CHEK2 phosphorylates TP53 (Bos taurus)
ADP [nucleoplasm]
CK2:FACT phosphorylates TP53 (Bos taurus)
ADP [nucleoplasm]
DYRK2 phosphorylates TP53 (Bos taurus)
ADP [nucleoplasm]
HIPK2 phosphorylates TP53 (Bos taurus)
ADP [nucleoplasm]
MAPKAPK5 phosphorylates TP53 (Bos taurus)
ADP [nucleoplasm]
NUAK1 phosphorylates TP53 (Bos taurus)
ADP [nucleoplasm]
PLK3 phosphorylates TP53 (Bos taurus)
ADP [nucleoplasm]
STK11 (LKB1) phosphorylates NUAK1 (Bos taurus)
ADP [nucleoplasm]
TAF1 phosphorylates TP53 (Bos taurus)
ADP [nucleoplasm]
TP53RK phosphorylates TP53 (Bos taurus)
ADP [nucleoplasm]
Regulation of TP53 Expression and Degradation (Bos taurus)
Regulation of TP53 Degradation (Bos taurus)
(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Bos taurus)
ADP [nucleoplasm]
ATM phosphorylates MDM2 (Bos taurus)
ADP [nucleoplasm]
TP53 Regulates Transcription of Cell Cycle Genes (Bos taurus)
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain (Bos taurus)
PLK3 phosphorylates CDC25C (Bos taurus)
ADP [nucleoplasm]
TP53 Regulates Transcription of Cell Death Genes (Bos taurus)
TP53 Regulates Transcription of Caspase Activators and Caspases (Bos taurus)
ATM phosphorylates PIDD1 (Bos taurus)
ADP [nucleoplasm]
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release (Bos taurus)
ATM phosphorylates ZNF420 (Bos taurus)
ADP [nucleoplasm]
TP53 Regulates Transcription of DNA Repair Genes (Bos taurus)
CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Bos taurus)
ADP [nucleoplasm]
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Bos taurus)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Bos taurus)
Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Bos taurus)
ADP [nucleoplasm]
Transcriptional regulation by RUNX1 (Bos taurus)
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known (Bos taurus)
HIPK2 phosphorylates RUNX1 (Bos taurus)
ADP [nucleoplasm]
HIPK2 phosphorylates RUNX1 and EP300 (Bos taurus)
ADP [nucleoplasm]
RUNX1 regulates transcription of genes involved in differentiation of HSCs (Bos taurus)
ABL1 phosphorylates YAP1 (Bos taurus)
ADP [nucleoplasm]
Transcriptional regulation by RUNX2 (Bos taurus)
CDK1 phosphorylates RUNX2 (Bos taurus)
ADP [nucleoplasm]
CDK4 phosphorylates RUNX2 (Bos taurus)
ADP [nucleoplasm]
RNA Pol II CTD phosphorylation and interaction with CE (Bos taurus)
Phosphorylation (Ser5) of RNA pol II CTD (Bos taurus)
ADP [nucleoplasm]
RNA Polymerase II Transcription Elongation (Bos taurus)
Formation of RNA Pol II elongation complex (Bos taurus)
Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Bos taurus)
ADP [nucleoplasm]
RNA Polymerase II Transcription Initiation And Promoter Clearance (Bos taurus)
RNA Polymerase II Promoter Opening: First Transition (Bos taurus)
ADP [nucleoplasm]
RNA polymerase II transcribes snRNA genes (Bos taurus)
CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Bos taurus)
ADP [nucleoplasm]
Immune System (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
Interferon Signaling (Bos taurus)
Antiviral mechanism by IFN-stimulated genes (Bos taurus)
PKR-mediated signaling (Bos taurus)
p-PKR dimer phosphorylates SPHK1 (Bos taurus)
ADP [nucleoplasm]
p-PKR dimer phosphorylates TP53 tetramer (Bos taurus)
ADP [nucleoplasm]
Signaling by Interleukins (Bos taurus)
Interleukin-17 signaling (Bos taurus)
MAP kinase activation (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
Activation of the AP-1 family of transcription factors (Bos taurus)
Activated JNKs phosphorylate c-JUN (Bos taurus)
ADP [nucleoplasm]
c-FOS activation by phospho ERK1/2 (Bos taurus)
ADP [nucleoplasm]
CREB phosphorylation (Bos taurus)
MAPKAPK2 phosphorylates CREB at Serine 133 (Bos taurus)
ADP [nucleoplasm]
MSK1 activates ATF1 (Bos taurus)
ADP [nucleoplasm]
MSK1 activates CREB (Bos taurus)
ADP [nucleoplasm]
RSK1/2/3 phosphorylates CREB at Serine 119 (Bos taurus)
ADP [nucleoplasm]
ERK/MAPK targets (Bos taurus)
ERK1/2 phosphorylates MSK1 (Bos taurus)
ADP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Bos taurus)
ADP [nucleoplasm]
p38MAPK phosphorylates MSK1 (Bos taurus)
ADP [nucleoplasm]
activated TAK1 mediates p38 MAPK activation (Bos taurus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Bos taurus)
ADP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Bos taurus)
ADP [nucleoplasm]
Innate Immune System (Bos taurus)
C-type lectin receptors (CLRs) (Bos taurus)
CD209 (DC-SIGN) signaling (Bos taurus)
Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit (Bos taurus)
ADP [nucleoplasm]
Fc epsilon receptor (FCERI) signaling (Bos taurus)
FCERI mediated MAPK activation (Bos taurus)
Activated JNKs phosphorylate c-JUN (Bos taurus)
ADP [nucleoplasm]
c-FOS activation by phospho ERK1/2 (Bos taurus)
ADP [nucleoplasm]
Toll-like Receptor Cascades (Bos taurus)
Toll Like Receptor 10 (TLR10) Cascade (Bos taurus)
MyD88 cascade initiated on plasma membrane (Bos taurus)
MAP kinase activation (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
Activation of the AP-1 family of transcription factors (Bos taurus)
Activated JNKs phosphorylate c-JUN (Bos taurus)
ADP [nucleoplasm]
c-FOS activation by phospho ERK1/2 (Bos taurus)
ADP [nucleoplasm]
CREB phosphorylation (Bos taurus)
MAPKAPK2 phosphorylates CREB at Serine 133 (Bos taurus)
ADP [nucleoplasm]
MSK1 activates ATF1 (Bos taurus)
ADP [nucleoplasm]
MSK1 activates CREB (Bos taurus)
ADP [nucleoplasm]
RSK1/2/3 phosphorylates CREB at Serine 119 (Bos taurus)
ADP [nucleoplasm]
ERK/MAPK targets (Bos taurus)
ERK1/2 phosphorylates MSK1 (Bos taurus)
ADP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Bos taurus)
ADP [nucleoplasm]
p38MAPK phosphorylates MSK1 (Bos taurus)
ADP [nucleoplasm]
activated TAK1 mediates p38 MAPK activation (Bos taurus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Bos taurus)
ADP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Bos taurus)
ADP [nucleoplasm]
Toll Like Receptor 2 (TLR2) Cascade (Bos taurus)
Toll Like Receptor TLR1:TLR2 Cascade (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
MAP kinase activation (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
Activation of the AP-1 family of transcription factors (Bos taurus)
Activated JNKs phosphorylate c-JUN (Bos taurus)
ADP [nucleoplasm]
c-FOS activation by phospho ERK1/2 (Bos taurus)
ADP [nucleoplasm]
CREB phosphorylation (Bos taurus)
MAPKAPK2 phosphorylates CREB at Serine 133 (Bos taurus)
ADP [nucleoplasm]
MSK1 activates ATF1 (Bos taurus)
ADP [nucleoplasm]
MSK1 activates CREB (Bos taurus)
ADP [nucleoplasm]
RSK1/2/3 phosphorylates CREB at Serine 119 (Bos taurus)
ADP [nucleoplasm]
ERK/MAPK targets (Bos taurus)
ERK1/2 phosphorylates MSK1 (Bos taurus)
ADP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Bos taurus)
ADP [nucleoplasm]
p38MAPK phosphorylates MSK1 (Bos taurus)
ADP [nucleoplasm]
activated TAK1 mediates p38 MAPK activation (Bos taurus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Bos taurus)
ADP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Bos taurus)
ADP [nucleoplasm]
Toll Like Receptor TLR6:TLR2 Cascade (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
MAP kinase activation (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
Activation of the AP-1 family of transcription factors (Bos taurus)
Activated JNKs phosphorylate c-JUN (Bos taurus)
ADP [nucleoplasm]
c-FOS activation by phospho ERK1/2 (Bos taurus)
ADP [nucleoplasm]
CREB phosphorylation (Bos taurus)
MAPKAPK2 phosphorylates CREB at Serine 133 (Bos taurus)
ADP [nucleoplasm]
MSK1 activates ATF1 (Bos taurus)
ADP [nucleoplasm]
MSK1 activates CREB (Bos taurus)
ADP [nucleoplasm]
RSK1/2/3 phosphorylates CREB at Serine 119 (Bos taurus)
ADP [nucleoplasm]
ERK/MAPK targets (Bos taurus)
ERK1/2 phosphorylates MSK1 (Bos taurus)
ADP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Bos taurus)
ADP [nucleoplasm]
p38MAPK phosphorylates MSK1 (Bos taurus)
ADP [nucleoplasm]
activated TAK1 mediates p38 MAPK activation (Bos taurus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Bos taurus)
ADP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Bos taurus)
ADP [nucleoplasm]
Toll Like Receptor 3 (TLR3) Cascade (Bos taurus)
MAP kinase activation (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
Activation of the AP-1 family of transcription factors (Bos taurus)
Activated JNKs phosphorylate c-JUN (Bos taurus)
ADP [nucleoplasm]
c-FOS activation by phospho ERK1/2 (Bos taurus)
ADP [nucleoplasm]
CREB phosphorylation (Bos taurus)
MAPKAPK2 phosphorylates CREB at Serine 133 (Bos taurus)
ADP [nucleoplasm]
MSK1 activates ATF1 (Bos taurus)
ADP [nucleoplasm]
MSK1 activates CREB (Bos taurus)
ADP [nucleoplasm]
RSK1/2/3 phosphorylates CREB at Serine 119 (Bos taurus)
ADP [nucleoplasm]
ERK/MAPK targets (Bos taurus)
ERK1/2 phosphorylates MSK1 (Bos taurus)
ADP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Bos taurus)
ADP [nucleoplasm]
p38MAPK phosphorylates MSK1 (Bos taurus)
ADP [nucleoplasm]
activated TAK1 mediates p38 MAPK activation (Bos taurus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Bos taurus)
ADP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Bos taurus)
ADP [nucleoplasm]
Toll Like Receptor 4 (TLR4) Cascade (Bos taurus)
MyD88-independent TLR4 cascade (Bos taurus)
TRIF (TICAM1)-mediated TLR4 signaling (Bos taurus)
MAP kinase activation (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
Activation of the AP-1 family of transcription factors (Bos taurus)
Activated JNKs phosphorylate c-JUN (Bos taurus)
ADP [nucleoplasm]
c-FOS activation by phospho ERK1/2 (Bos taurus)
ADP [nucleoplasm]
CREB phosphorylation (Bos taurus)
MAPKAPK2 phosphorylates CREB at Serine 133 (Bos taurus)
ADP [nucleoplasm]
MSK1 activates ATF1 (Bos taurus)
ADP [nucleoplasm]
MSK1 activates CREB (Bos taurus)
ADP [nucleoplasm]
RSK1/2/3 phosphorylates CREB at Serine 119 (Bos taurus)
ADP [nucleoplasm]
ERK/MAPK targets (Bos taurus)
ERK1/2 phosphorylates MSK1 (Bos taurus)
ADP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Bos taurus)
ADP [nucleoplasm]
p38MAPK phosphorylates MSK1 (Bos taurus)
ADP [nucleoplasm]
activated TAK1 mediates p38 MAPK activation (Bos taurus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Bos taurus)
ADP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Bos taurus)
ADP [nucleoplasm]
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
MAP kinase activation (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
Activation of the AP-1 family of transcription factors (Bos taurus)
Activated JNKs phosphorylate c-JUN (Bos taurus)
ADP [nucleoplasm]
c-FOS activation by phospho ERK1/2 (Bos taurus)
ADP [nucleoplasm]
CREB phosphorylation (Bos taurus)
MAPKAPK2 phosphorylates CREB at Serine 133 (Bos taurus)
ADP [nucleoplasm]
MSK1 activates ATF1 (Bos taurus)
ADP [nucleoplasm]
MSK1 activates CREB (Bos taurus)
ADP [nucleoplasm]
RSK1/2/3 phosphorylates CREB at Serine 119 (Bos taurus)
ADP [nucleoplasm]
ERK/MAPK targets (Bos taurus)
ERK1/2 phosphorylates MSK1 (Bos taurus)
ADP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Bos taurus)
ADP [nucleoplasm]
p38MAPK phosphorylates MSK1 (Bos taurus)
ADP [nucleoplasm]
activated TAK1 mediates p38 MAPK activation (Bos taurus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Bos taurus)
ADP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Bos taurus)
ADP [nucleoplasm]
Toll Like Receptor 5 (TLR5) Cascade (Bos taurus)
MyD88 cascade initiated on plasma membrane (Bos taurus)
MAP kinase activation (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
Activation of the AP-1 family of transcription factors (Bos taurus)
Activated JNKs phosphorylate c-JUN (Bos taurus)
ADP [nucleoplasm]
c-FOS activation by phospho ERK1/2 (Bos taurus)
ADP [nucleoplasm]
CREB phosphorylation (Bos taurus)
MAPKAPK2 phosphorylates CREB at Serine 133 (Bos taurus)
ADP [nucleoplasm]
MSK1 activates ATF1 (Bos taurus)
ADP [nucleoplasm]
MSK1 activates CREB (Bos taurus)
ADP [nucleoplasm]
RSK1/2/3 phosphorylates CREB at Serine 119 (Bos taurus)
ADP [nucleoplasm]
ERK/MAPK targets (Bos taurus)
ERK1/2 phosphorylates MSK1 (Bos taurus)
ADP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Bos taurus)
ADP [nucleoplasm]
p38MAPK phosphorylates MSK1 (Bos taurus)
ADP [nucleoplasm]
activated TAK1 mediates p38 MAPK activation (Bos taurus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Bos taurus)
ADP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Bos taurus)
ADP [nucleoplasm]
Toll Like Receptor 7/8 (TLR7/8) Cascade (Bos taurus)
MyD88 dependent cascade initiated on endosome (Bos taurus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)
MAP kinase activation (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
Activation of the AP-1 family of transcription factors (Bos taurus)
Activated JNKs phosphorylate c-JUN (Bos taurus)
ADP [nucleoplasm]
c-FOS activation by phospho ERK1/2 (Bos taurus)
ADP [nucleoplasm]
CREB phosphorylation (Bos taurus)
MAPKAPK2 phosphorylates CREB at Serine 133 (Bos taurus)
ADP [nucleoplasm]
MSK1 activates ATF1 (Bos taurus)
ADP [nucleoplasm]
MSK1 activates CREB (Bos taurus)
ADP [nucleoplasm]
RSK1/2/3 phosphorylates CREB at Serine 119 (Bos taurus)
ADP [nucleoplasm]
ERK/MAPK targets (Bos taurus)
ERK1/2 phosphorylates MSK1 (Bos taurus)
ADP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Bos taurus)
ADP [nucleoplasm]
p38MAPK phosphorylates MSK1 (Bos taurus)
ADP [nucleoplasm]
activated TAK1 mediates p38 MAPK activation (Bos taurus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Bos taurus)
ADP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Bos taurus)
ADP [nucleoplasm]
Toll Like Receptor 9 (TLR9) Cascade (Bos taurus)
MyD88 dependent cascade initiated on endosome (Bos taurus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)
MAP kinase activation (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
Activation of the AP-1 family of transcription factors (Bos taurus)
Activated JNKs phosphorylate c-JUN (Bos taurus)
ADP [nucleoplasm]
c-FOS activation by phospho ERK1/2 (Bos taurus)
ADP [nucleoplasm]
CREB phosphorylation (Bos taurus)
MAPKAPK2 phosphorylates CREB at Serine 133 (Bos taurus)
ADP [nucleoplasm]
MSK1 activates ATF1 (Bos taurus)
ADP [nucleoplasm]
MSK1 activates CREB (Bos taurus)
ADP [nucleoplasm]
RSK1/2/3 phosphorylates CREB at Serine 119 (Bos taurus)
ADP [nucleoplasm]
ERK/MAPK targets (Bos taurus)
ERK1/2 phosphorylates MSK1 (Bos taurus)
ADP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Bos taurus)
ADP [nucleoplasm]
p38MAPK phosphorylates MSK1 (Bos taurus)
ADP [nucleoplasm]
activated TAK1 mediates p38 MAPK activation (Bos taurus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Bos taurus)
ADP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Bos taurus)
ADP [nucleoplasm]
Metabolism (Bos taurus)
Inositol phosphate metabolism (Bos taurus)
Synthesis of IPs in the nucleus (Bos taurus)
1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Bos taurus)
ADP [nucleoplasm]
5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Bos taurus)
ADP [nucleoplasm]
5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Bos taurus)
ADP [nucleoplasm]
I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Bos taurus)
ADP [nucleoplasm]
I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Bos taurus)
ADP [nucleoplasm]
I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus (Bos taurus)
ADP [nucleoplasm]
I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Bos taurus)
ADP [nucleoplasm]
I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Bos taurus)
ADP [nucleoplasm]
I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Bos taurus)
ADP [nucleoplasm]
IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Bos taurus)
ADP [nucleoplasm]
Metabolism of lipids (Bos taurus)
Phospholipid metabolism (Bos taurus)
PI Metabolism (Bos taurus)
Synthesis of PIPs in the nucleus (Bos taurus)
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Bos taurus)
ADP [nucleoplasm]
Metabolism of nucleotides (Bos taurus)
Interconversion of nucleotide di- and triphosphates (Bos taurus)
AK6 phosphorylates (d)NMPs to (d)NDPs (Bos taurus)
(d)NDPs [nucleoplasm]
ADP [nucleoplasm]
ADP [nucleoplasm]
Metabolism of RNA (Bos taurus)
Processing of Capped Intron-Containing Pre-mRNA (Bos taurus)
Transport of Mature Transcript to Cytoplasm (Bos taurus)
Transport of Mature mRNA derived from an Intron-Containing Transcript (Bos taurus)
NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Bos taurus)
DDX39B:ADP [nucleoplasm] (Bos taurus)
ADP [nucleoplasm]
mRNA Splicing (Bos taurus)
mRNA Splicing - Major Pathway (Bos taurus)
Formation of the Spliceosomal Bact complex (Bos taurus)
ADP [nucleoplasm]
Formation of the Spliceosomal C* complex (Bos taurus)
ADP [nucleoplasm]
Regulation of mRNA stability by proteins that bind AU-rich elements (Bos taurus)
HuR (ELAVL1) binds and stabilizes mRNA (Bos taurus)
PKCdelta phosphorylates HuR (Bos taurus)
ADP [nucleoplasm]
Neuronal System (Bos taurus)
Transmission across Chemical Synapses (Bos taurus)
Neurotransmitter receptors and postsynaptic signal transmission (Bos taurus)
Activation of NMDA receptors and postsynaptic events (Bos taurus)
Post NMDA receptor activation events (Bos taurus)
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling (Bos taurus)
Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) (Bos taurus)
ADP [nucleoplasm]
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde (Bos taurus)
CAMK4 autophosphorylates (Bos taurus)
ADP [nucleoplasm]
CaMKK autophosphorylates in the nucleus (Bos taurus)
ADP [nucleoplasm]
Signal Transduction (Bos taurus)
Intracellular signaling by second messengers (Bos taurus)
DAG and IP3 signaling (Bos taurus)
CaM pathway (Bos taurus)
Calmodulin induced events (Bos taurus)
CaMK IV-mediated phosphorylation of CREB (Bos taurus)
CAMK4 autophosphorylates (Bos taurus)
ADP [nucleoplasm]
CaMKK autophosphorylates in the nucleus (Bos taurus)
ADP [nucleoplasm]
MAPK family signaling cascades (Bos taurus)
MAPK6/MAPK4 signaling (Bos taurus)
CDK1 phosphorylates MAPK6 (Bos taurus)
ADP [nucleoplasm]
PKA phosphorylates MAPKAPK5 (Bos taurus)
ADP [nucleoplasm]
p-S MAPK6 phosphorylates NCOA3 (Bos taurus)
ADP [nucleoplasm]
p-S MAPK6,4 phosphorylate MAPKAPK5 (Bos taurus)
ADP [nucleoplasm]
p-T182 MAPKAPK5 phosphorylates FOXO1 (Bos taurus)
ADP [nucleoplasm]
Signaling by GPCR (Bos taurus)
GPCR downstream signalling (Bos taurus)
G alpha (i) signalling events (Bos taurus)
Opioid Signalling (Bos taurus)
G-protein mediated events (Bos taurus)
PLC beta mediated events (Bos taurus)
Ca-dependent events (Bos taurus)
CaM pathway (Bos taurus)
Calmodulin induced events (Bos taurus)
CaMK IV-mediated phosphorylation of CREB (Bos taurus)
CAMK4 autophosphorylates (Bos taurus)
ADP [nucleoplasm]
CaMKK autophosphorylates in the nucleus (Bos taurus)
ADP [nucleoplasm]
G alpha (q) signalling events (Bos taurus)
Gastrin-CREB signalling pathway via PKC and MAPK (Bos taurus)
ERK1/2/5 activate RSK1/2/3 (Bos taurus)
ADP [nucleoplasm]
RSK1/2/3 phosphorylates CREB at Serine 119 (Bos taurus)
ADP [nucleoplasm]
Signaling by NOTCH (Bos taurus)
Pre-NOTCH Expression and Processing (Bos taurus)
Pre-NOTCH Transcription and Translation (Bos taurus)
PRKCI phosphorylates ELF3 (Bos taurus)
ADP [nucleoplasm]
Signaling by Non-Receptor Tyrosine Kinases (Bos taurus)
Signaling by PTK6 (Bos taurus)
PTK6 Regulates Proteins Involved in RNA Processing (Bos taurus)
PTK6 phosphorylates KHDRBS1 (Bos taurus)
ADP [nucleoplasm]
PTK6 phosphorylates KHDRBS2 (Bos taurus)
ADP [nucleoplasm]
PTK6 phosphorylates KHDRBS3 (Bos taurus)
ADP [nucleoplasm]
PTK6 phosphorylates SFPQ (Bos taurus)
ADP [nucleoplasm]
Signaling by Nuclear Receptors (Bos taurus)
ESR-mediated signaling (Bos taurus)
Estrogen-dependent gene expression (Bos taurus)
Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG (Bos taurus)
ADP [nucleoplasm]
p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Bos taurus)
ADP [nucleoplasm]
Extra-nuclear estrogen signaling (Bos taurus)
Estrogen-dependent nuclear events downstream of ESR-membrane signaling (Bos taurus)
CDKN1B is phosphorylated in response to estrogen (Bos taurus)
ADP [nucleoplasm]
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by NTRKs (Bos taurus)
Signaling by NTRK1 (TRKA) (Bos taurus)
Nuclear Events (kinase and transcription factor activation) (Bos taurus)
CREB phosphorylation (Bos taurus)
MAPKAPK2 phosphorylates CREB at Serine 133 (Bos taurus)
ADP [nucleoplasm]
MSK1 activates ATF1 (Bos taurus)
ADP [nucleoplasm]
MSK1 activates CREB (Bos taurus)
ADP [nucleoplasm]
RSK1/2/3 phosphorylates CREB at Serine 119 (Bos taurus)
ADP [nucleoplasm]
ERK/MAPK targets (Bos taurus)
ERK1/2 phosphorylates MSK1 (Bos taurus)
ADP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Bos taurus)
ADP [nucleoplasm]
p38MAPK phosphorylates MSK1 (Bos taurus)
ADP [nucleoplasm]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Bos taurus)
Signaling by Rho GTPases (Bos taurus)
RHO GTPase Effectors (Bos taurus)
RHO GTPases activate PKNs (Bos taurus)
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (Bos taurus)
PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Bos taurus)
ADP [nucleoplasm]
Signaling by TGFB family members (Bos taurus)
Signaling by TGF-beta Receptor Complex (Bos taurus)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Bos taurus)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Bos taurus)
Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Bos taurus)
ADP [nucleoplasm]
Signaling by WNT (Bos taurus)
Beta-catenin independent WNT signaling (Bos taurus)
Ca2+ pathway (Bos taurus)
NLK phosphorylates TCF/LEF (Bos taurus)
ADP [nucleoplasm]
TCF dependent signaling in response to WNT (Bos taurus)
Deactivation of the beta-catenin transactivating complex (Bos taurus)
AKT phosphorylates CBY1 (Bos taurus)
ADP [nucleoplasm]
Cell Cycle (Caenorhabditis elegans)
Cell Cycle Checkpoints (Caenorhabditis elegans)
G1/S DNA Damage Checkpoints (Caenorhabditis elegans)
p53-Independent G1/S DNA damage checkpoint (Caenorhabditis elegans)
p53-Independent DNA Damage Response (Caenorhabditis elegans)
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A (Caenorhabditis elegans)
Phosphorylation of Cdc25A at Ser-123 by Chk1 (Caenorhabditis elegans)
ADP [nucleoplasm]
Phosphorylation of Cdc25A at Ser-123 by Chk2 (Caenorhabditis elegans)
ADP [nucleoplasm]
G2/M Checkpoints (Caenorhabditis elegans)
Activation of ATR in response to replication stress (Caenorhabditis elegans)
Phosphorylation of Cdc25A at Ser-123 by Chk1 (Caenorhabditis elegans)
ADP [nucleoplasm]
Phosphorylation of Cdc25C at Ser 216 by Chk1 (Caenorhabditis elegans)
ADP [nucleoplasm]
G2/M DNA damage checkpoint (Caenorhabditis elegans)
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex (Caenorhabditis elegans)
Phosphorylation of Cdc25C at Ser216 by CHEK2 (Caenorhabditis elegans)
ADP [nucleoplasm]
p-T68-CHEK2 autophosphorylates (Caenorhabditis elegans)
ADP [nucleoplasm]
Cell Cycle, Mitotic (Caenorhabditis elegans)
M Phase (Caenorhabditis elegans)
Mitotic Prophase (Caenorhabditis elegans)
Condensation of Prophase Chromosomes (Caenorhabditis elegans)
CDK1 phosphorylates condensin II subunit NCAPD3 (Caenorhabditis elegans)
ADP [nucleoplasm]
PLK1 hyperphosphorylates Condensin II complex (Caenorhabditis elegans)
ADP [nucleoplasm]
Nuclear Envelope Breakdown (Caenorhabditis elegans)
Depolymerization of the Nuclear Lamina (Caenorhabditis elegans)
CDK1 phosphorylates LPIN (Caenorhabditis elegans)
ADP [nucleoplasm]
CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Caenorhabditis elegans)
ADP [nucleoplasm]
Mitotic Telophase/Cytokinesis (Caenorhabditis elegans)
Regulation of KIF23 (MKLP1) by phosphorylation (Caenorhabditis elegans)
ADP [nucleoplasm]
Mitotic G1 phase and G1/S transition (Caenorhabditis elegans)
G0 and Early G1 (Caenorhabditis elegans)
Phosphorylation of LIN52 component of MuvB by DYRK1A (Caenorhabditis elegans)
ADP [nucleoplasm]
G1/S Transition (Caenorhabditis elegans)
Cyclin E associated events during G1/S transition (Caenorhabditis elegans)
SCF(Skp2)-mediated degradation of p27/p21 (Caenorhabditis elegans)
Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21 (Caenorhabditis elegans)
ADP [nucleoplasm]
Mitotic G2-G2/M phases (Caenorhabditis elegans)
G2/M Transition (Caenorhabditis elegans)
Polo-like kinase mediated events (Caenorhabditis elegans)
Inactivation of Myt1 kinase (Caenorhabditis elegans)
ADP [nucleoplasm]
S Phase (Caenorhabditis elegans)
Cyclin A:Cdk2-associated events at S phase entry (Caenorhabditis elegans)
Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Caenorhabditis elegans)
ADP [nucleoplasm]
SCF(Skp2)-mediated degradation of p27/p21 (Caenorhabditis elegans)
Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21 (Caenorhabditis elegans)
ADP [nucleoplasm]
Synthesis of DNA (Caenorhabditis elegans)
DNA strand elongation (Caenorhabditis elegans)
Lagging Strand Synthesis (Caenorhabditis elegans)
Polymerase switching (Caenorhabditis elegans)
Loading of PCNA - Sliding Clamp Formation (Caenorhabditis elegans)
ADP [nucleoplasm]
Leading Strand Synthesis (Caenorhabditis elegans)
Polymerase switching (Caenorhabditis elegans)
Loading of PCNA - Sliding Clamp Formation (Caenorhabditis elegans)
ADP [nucleoplasm]
Switching of origins to a post-replicative state (Caenorhabditis elegans)
CDK-mediated phosphorylation and removal of Cdc6 (Caenorhabditis elegans)
Cdc6 protein is phosphorylated by CDK (Caenorhabditis elegans)
ADP [nucleoplasm]
Orc1 removal from chromatin (Caenorhabditis elegans)
Orc1 is phosphorylated by cyclin A/CDK2 (Caenorhabditis elegans)
ADP [nucleoplasm]
Cellular responses to stimuli (Caenorhabditis elegans)
Cellular responses to stress (Caenorhabditis elegans)
Cellular Senescence (Caenorhabditis elegans)
Oxidative Stress Induced Senescence (Caenorhabditis elegans)
Activated JNKs phosphorylate c-JUN (Caenorhabditis elegans)
ADP [nucleoplasm]
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Caenorhabditis elegans)
ADP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Caenorhabditis elegans)
ADP [nucleoplasm]
c-FOS activation by phospho ERK1/2 (Caenorhabditis elegans)
ADP [nucleoplasm]
Senescence-Associated Secretory Phenotype (SASP) (Caenorhabditis elegans)
ERK1/2/5 activate RSK1/2/3 (Caenorhabditis elegans)
ADP [nucleoplasm]
Cellular response to chemical stress (Caenorhabditis elegans)
KEAP1-NFE2L2 pathway (Caenorhabditis elegans)
Nuclear events mediated by NFE2L2 (Caenorhabditis elegans)
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Caenorhabditis elegans)
GSK3B phosphorylates p-NFE2L2 (Caenorhabditis elegans)
ADP [nucleoplasm]
PRKAA2 phosphorylates nuclear NFE2L2 (Caenorhabditis elegans)
ADP [nucleoplasm]
Cellular response to heat stress (Caenorhabditis elegans)
HSF1-dependent transactivation (Caenorhabditis elegans)
Phosphorylation of HSF1 at Ser230 induces transactivation (Caenorhabditis elegans)
ADP [nucleoplasm]
Phosphorylation of HSF1 at Ser326 induces transactivation (Caenorhabditis elegans)
ADP [nucleoplasm]
Regulation of HSF1-mediated heat shock response (Caenorhabditis elegans)
HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Caenorhabditis elegans)
HSP70s:ADP [nucleoplasm] (Caenorhabditis elegans)
HSPA13:ADP [nucleoplasm] (Caenorhabditis elegans)
ADP [nucleoplasm]
HSPA1A:ADP [nucleoplasm] (Caenorhabditis elegans)
ADP [nucleoplasm]
HSPA1L:ADP [nucleoplasm] (Caenorhabditis elegans)
ADP [nucleoplasm]
HSPA2:ADP [nucleoplasm] (Caenorhabditis elegans)
ADP [nucleoplasm]
HSPA4:ADP [nucleoplasm] (Caenorhabditis elegans)
ADP [nucleoplasm]
HSPA4L:ADP [nucleoplasm] (Caenorhabditis elegans)
ADP [nucleoplasm]
HSPA5:ADP [nucleoplasm] (Caenorhabditis elegans)
ADP [nucleoplasm]
HSPA6:ADP [nucleoplasm] (Caenorhabditis elegans)
ADP [nucleoplasm]
HSPA8:ADP [nucleoplasm] (Caenorhabditis elegans)
ADP [nucleoplasm]
HSPA9:ADP [nucleoplasm] (Caenorhabditis elegans)
ADP [nucleoplasm]
DNA Repair (Caenorhabditis elegans)
DNA Damage Bypass (Caenorhabditis elegans)
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Caenorhabditis elegans)
Translesion Synthesis by POLH (Caenorhabditis elegans)
SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Caenorhabditis elegans)
ADP [nucleoplasm]
DNA Double-Strand Break Repair (Caenorhabditis elegans)
DNA Double Strand Break Response (Caenorhabditis elegans)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Caenorhabditis elegans)
p-T68-CHEK2 autophosphorylates (Caenorhabditis elegans)
ADP [nucleoplasm]
Homology Directed Repair (Caenorhabditis elegans)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Caenorhabditis elegans)
HDR through Homologous Recombination (HRR) (Caenorhabditis elegans)
Homologous DNA Pairing and Strand Exchange (Caenorhabditis elegans)
Presynaptic phase of homologous DNA pairing and strand exchange (Caenorhabditis elegans)
CHEK1 phosphorylates RAD51 (Caenorhabditis elegans)
ADP [nucleoplasm]
Processing of DNA double-strand break ends (Caenorhabditis elegans)
ATR phosphorylates RPA2 (Caenorhabditis elegans)
ADP [nucleoplasm]
Mismatch Repair (Caenorhabditis elegans)
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (Caenorhabditis elegans)
Formation of MSH2:MSH6 Complex (Caenorhabditis elegans)
ADP [nucleoplasm]
MSH2:MSH6:ADP [nucleoplasm] (Caenorhabditis elegans)
ADP [nucleoplasm]
MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Caenorhabditis elegans)
MSH2:MSH6:ADP [nucleoplasm] (Caenorhabditis elegans)
ADP [nucleoplasm]
MSH2:MSH6:ADP:DNA containing 1-2 base mismatch [nucleoplasm] (Caenorhabditis elegans)
MSH2:MSH6:ADP [nucleoplasm] (Caenorhabditis elegans)
ADP [nucleoplasm]
MSH2:MSH6 exchanges ADP for ATP (Caenorhabditis elegans)
ADP [nucleoplasm]
MSH2:MSH6:ADP:DNA containing 1-2 base mismatch [nucleoplasm] (Caenorhabditis elegans)
MSH2:MSH6:ADP [nucleoplasm] (Caenorhabditis elegans)
ADP [nucleoplasm]
Nucleotide Excision Repair (Caenorhabditis elegans)
Global Genome Nucleotide Excision Repair (GG-NER) (Caenorhabditis elegans)
Formation of Incision Complex in GG-NER (Caenorhabditis elegans)
ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Caenorhabditis elegans)
ADP [nucleoplasm]
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Caenorhabditis elegans)
Dual incision in TC-NER (Caenorhabditis elegans)
ERCC2-facilitated RNA Pol II backtracking in TC-NER (Caenorhabditis elegans)
ADP [nucleoplasm]
ERCC3-facilitated RNA Pol II backtracking in TC-NER (Caenorhabditis elegans)
ADP [nucleoplasm]
DNA Replication (Caenorhabditis elegans)
Synthesis of DNA (Caenorhabditis elegans)
DNA strand elongation (Caenorhabditis elegans)
Lagging Strand Synthesis (Caenorhabditis elegans)
Polymerase switching (Caenorhabditis elegans)
Loading of PCNA - Sliding Clamp Formation (Caenorhabditis elegans)
ADP [nucleoplasm]
Leading Strand Synthesis (Caenorhabditis elegans)
Polymerase switching (Caenorhabditis elegans)
Loading of PCNA - Sliding Clamp Formation (Caenorhabditis elegans)
ADP [nucleoplasm]
Switching of origins to a post-replicative state (Caenorhabditis elegans)
CDK-mediated phosphorylation and removal of Cdc6 (Caenorhabditis elegans)
Cdc6 protein is phosphorylated by CDK (Caenorhabditis elegans)
ADP [nucleoplasm]
Orc1 removal from chromatin (Caenorhabditis elegans)
Orc1 is phosphorylated by cyclin A/CDK2 (Caenorhabditis elegans)
ADP [nucleoplasm]
Developmental Biology (Caenorhabditis elegans)
MITF-M-regulated melanocyte development (Caenorhabditis elegans)
Transcriptional and post-translational regulation of MITF-M expression and activity (Caenorhabditis elegans)
AKT3 phosphorylates TBX3 (Caenorhabditis elegans)
ADP [nucleoplasm]
GSK3B phosphorylates p-S409 MITF-M at S397, S401 and S405 (Caenorhabditis elegans)
ADP [nucleoplasm]
GSK3B phosphorylates p-S73 MITF-M at residue S69 (Caenorhabditis elegans)
ADP [nucleoplasm]
MAPK1-dependent phosphorylation of MITF-M (Caenorhabditis elegans)
ADP [nucleoplasm]
RPS6KA1-dependent phosphorylation of MITF-M (Caenorhabditis elegans)
ADP [nucleoplasm]
Myogenesis (Caenorhabditis elegans)
Phosphorylation of MEF2 proteins by p38 (Caenorhabditis elegans)
ADP [nucleoplasm]
Nervous system development (Caenorhabditis elegans)
Axon guidance (Caenorhabditis elegans)
NCAM signaling for neurite out-growth (Caenorhabditis elegans)
ERK1/2 phosphorylates MSK1 (Caenorhabditis elegans)
ADP [nucleoplasm]
MSK1 activates CREB (Caenorhabditis elegans)
ADP [nucleoplasm]
Regulation of beta-cell development (Caenorhabditis elegans)
Regulation of gene expression in beta cells (Caenorhabditis elegans)
AKT-mediated inactivation of FOXO1A (Caenorhabditis elegans)
AKT phosphorylates FOXO1A (Caenorhabditis elegans)
ADP [nucleoplasm]
Gene expression (Transcription) (Caenorhabditis elegans)
Epigenetic regulation of gene expression (Caenorhabditis elegans)
Epigenetic regulation by WDR5-containing histone modifying complexes (Caenorhabditis elegans)
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes (Caenorhabditis elegans)
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes (Caenorhabditis elegans)
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis (Caenorhabditis elegans)
ABL1 phosphorylates PPARG2 (Caenorhabditis elegans)
ADP [nucleoplasm]
RNA Polymerase II Transcription (Caenorhabditis elegans)
Generic Transcription Pathway (Caenorhabditis elegans)
FOXO-mediated transcription (Caenorhabditis elegans)
Regulation of localization of FOXO transcription factors (Caenorhabditis elegans)
AKT phosphorylates FOXO transcription factors (Caenorhabditis elegans)
ADP [nucleoplasm]
Transcriptional Regulation by TP53 (Caenorhabditis elegans)
Regulation of TP53 Activity (Caenorhabditis elegans)
Regulation of TP53 Activity through Acetylation (Caenorhabditis elegans)
AKT phosphorylates KAT6A (Caenorhabditis elegans)
ADP [nucleoplasm]
PI5P Regulates TP53 Acetylation (Caenorhabditis elegans)
MAP2K6 phosphorylates PIP4K2B (Caenorhabditis elegans)
ADP [nucleoplasm]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Caenorhabditis elegans)
ADP [nucleoplasm]
Regulation of TP53 Activity through Methylation (Caenorhabditis elegans)
CHEK2 phosphorylates TTC5 (Caenorhabditis elegans)
ADP [nucleoplasm]
TP53 Regulates Transcription of DNA Repair Genes (Caenorhabditis elegans)
CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Caenorhabditis elegans)
ADP [nucleoplasm]
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Caenorhabditis elegans)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Caenorhabditis elegans)
Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Caenorhabditis elegans)
ADP [nucleoplasm]
Transcriptional regulation by RUNX1 (Caenorhabditis elegans)
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known (Caenorhabditis elegans)
HIPK2 phosphorylates RUNX1 (Caenorhabditis elegans)
ADP [nucleoplasm]
HIPK2 phosphorylates RUNX1 and EP300 (Caenorhabditis elegans)
ADP [nucleoplasm]
RUNX1 regulates transcription of genes involved in differentiation of HSCs (Caenorhabditis elegans)
ABL1 phosphorylates YAP1 (Caenorhabditis elegans)
ADP [nucleoplasm]
Transcriptional regulation by RUNX2 (Caenorhabditis elegans)
CDK1 phosphorylates RUNX2 (Caenorhabditis elegans)
ADP [nucleoplasm]
RNA Pol II CTD phosphorylation and interaction with CE (Caenorhabditis elegans)
Phosphorylation (Ser5) of RNA pol II CTD (Caenorhabditis elegans)
ADP [nucleoplasm]
RNA Polymerase II Transcription Initiation And Promoter Clearance (Caenorhabditis elegans)
RNA Polymerase II Promoter Opening: First Transition (Caenorhabditis elegans)
ADP [nucleoplasm]
RNA polymerase II transcribes snRNA genes (Caenorhabditis elegans)
CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Caenorhabditis elegans)
ADP [nucleoplasm]
Immune System (Caenorhabditis elegans)
Cytokine Signaling in Immune system (Caenorhabditis elegans)
FLT3 Signaling (Caenorhabditis elegans)
AKT phosphorylates FOXO3 downstream of FLT3 (Caenorhabditis elegans)
ADP [nucleoplasm]
Interferon Signaling (Caenorhabditis elegans)
Antiviral mechanism by IFN-stimulated genes (Caenorhabditis elegans)
PKR-mediated signaling (Caenorhabditis elegans)
p-PKR dimer phosphorylates SPHK1 (Caenorhabditis elegans)
ADP [nucleoplasm]
Signaling by Interleukins (Caenorhabditis elegans)
Interleukin-17 signaling (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
Activation of the AP-1 family of transcription factors (Caenorhabditis elegans)
Activated JNKs phosphorylate c-JUN (Caenorhabditis elegans)
ADP [nucleoplasm]
Phosphorylated MAPKs phosphorylate ATF-2 (Caenorhabditis elegans)
ADP [nucleoplasm]
c-FOS activation by phospho ERK1/2 (Caenorhabditis elegans)
ADP [nucleoplasm]
CREB phosphorylation (Caenorhabditis elegans)
MAPKAPK2 phosphorylates CREB at Serine 133 (Caenorhabditis elegans)
ADP [nucleoplasm]
MSK1 activates ATF1 (Caenorhabditis elegans)
ADP [nucleoplasm]
MSK1 activates CREB (Caenorhabditis elegans)
ADP [nucleoplasm]
RSK1/2/3 phosphorylates CREB at Serine 119 (Caenorhabditis elegans)
ADP [nucleoplasm]
ERK/MAPK targets (Caenorhabditis elegans)
ERK1/2 phosphorylates MSK1 (Caenorhabditis elegans)
ADP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Caenorhabditis elegans)
ADP [nucleoplasm]
p38MAPK phosphorylates MSK1 (Caenorhabditis elegans)
ADP [nucleoplasm]
activated TAK1 mediates p38 MAPK activation (Caenorhabditis elegans)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Caenorhabditis elegans)
ADP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Caenorhabditis elegans)
ADP [nucleoplasm]
Innate Immune System (Caenorhabditis elegans)
Fc epsilon receptor (FCERI) signaling (Caenorhabditis elegans)
FCERI mediated MAPK activation (Caenorhabditis elegans)
Activated JNKs phosphorylate c-JUN (Caenorhabditis elegans)
ADP [nucleoplasm]
c-FOS activation by phospho ERK1/2 (Caenorhabditis elegans)
ADP [nucleoplasm]
Toll-like Receptor Cascades (Caenorhabditis elegans)
Toll Like Receptor 10 (TLR10) Cascade (Caenorhabditis elegans)
MyD88 cascade initiated on plasma membrane (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
Activation of the AP-1 family of transcription factors (Caenorhabditis elegans)
Activated JNKs phosphorylate c-JUN (Caenorhabditis elegans)
ADP [nucleoplasm]
Phosphorylated MAPKs phosphorylate ATF-2 (Caenorhabditis elegans)
ADP [nucleoplasm]
c-FOS activation by phospho ERK1/2 (Caenorhabditis elegans)
ADP [nucleoplasm]
CREB phosphorylation (Caenorhabditis elegans)
MAPKAPK2 phosphorylates CREB at Serine 133 (Caenorhabditis elegans)
ADP [nucleoplasm]
MSK1 activates ATF1 (Caenorhabditis elegans)
ADP [nucleoplasm]
MSK1 activates CREB (Caenorhabditis elegans)
ADP [nucleoplasm]
RSK1/2/3 phosphorylates CREB at Serine 119 (Caenorhabditis elegans)
ADP [nucleoplasm]
ERK/MAPK targets (Caenorhabditis elegans)
ERK1/2 phosphorylates MSK1 (Caenorhabditis elegans)
ADP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Caenorhabditis elegans)
ADP [nucleoplasm]
p38MAPK phosphorylates MSK1 (Caenorhabditis elegans)
ADP [nucleoplasm]
activated TAK1 mediates p38 MAPK activation (Caenorhabditis elegans)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Caenorhabditis elegans)
ADP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Caenorhabditis elegans)
ADP [nucleoplasm]
Toll Like Receptor 2 (TLR2) Cascade (Caenorhabditis elegans)
Toll Like Receptor TLR1:TLR2 Cascade (Caenorhabditis elegans)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
Activation of the AP-1 family of transcription factors (Caenorhabditis elegans)
Activated JNKs phosphorylate c-JUN (Caenorhabditis elegans)
ADP [nucleoplasm]
Phosphorylated MAPKs phosphorylate ATF-2 (Caenorhabditis elegans)
ADP [nucleoplasm]
c-FOS activation by phospho ERK1/2 (Caenorhabditis elegans)
ADP [nucleoplasm]
CREB phosphorylation (Caenorhabditis elegans)
MAPKAPK2 phosphorylates CREB at Serine 133 (Caenorhabditis elegans)
ADP [nucleoplasm]
MSK1 activates ATF1 (Caenorhabditis elegans)
ADP [nucleoplasm]
MSK1 activates CREB (Caenorhabditis elegans)
ADP [nucleoplasm]
RSK1/2/3 phosphorylates CREB at Serine 119 (Caenorhabditis elegans)
ADP [nucleoplasm]
ERK/MAPK targets (Caenorhabditis elegans)
ERK1/2 phosphorylates MSK1 (Caenorhabditis elegans)
ADP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Caenorhabditis elegans)
ADP [nucleoplasm]
p38MAPK phosphorylates MSK1 (Caenorhabditis elegans)
ADP [nucleoplasm]
activated TAK1 mediates p38 MAPK activation (Caenorhabditis elegans)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Caenorhabditis elegans)
ADP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Caenorhabditis elegans)
ADP [nucleoplasm]
Toll Like Receptor TLR6:TLR2 Cascade (Caenorhabditis elegans)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
Activation of the AP-1 family of transcription factors (Caenorhabditis elegans)
Activated JNKs phosphorylate c-JUN (Caenorhabditis elegans)
ADP [nucleoplasm]
Phosphorylated MAPKs phosphorylate ATF-2 (Caenorhabditis elegans)
ADP [nucleoplasm]
c-FOS activation by phospho ERK1/2 (Caenorhabditis elegans)
ADP [nucleoplasm]
CREB phosphorylation (Caenorhabditis elegans)
MAPKAPK2 phosphorylates CREB at Serine 133 (Caenorhabditis elegans)
ADP [nucleoplasm]
MSK1 activates ATF1 (Caenorhabditis elegans)
ADP [nucleoplasm]
MSK1 activates CREB (Caenorhabditis elegans)
ADP [nucleoplasm]
RSK1/2/3 phosphorylates CREB at Serine 119 (Caenorhabditis elegans)
ADP [nucleoplasm]
ERK/MAPK targets (Caenorhabditis elegans)
ERK1/2 phosphorylates MSK1 (Caenorhabditis elegans)
ADP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Caenorhabditis elegans)
ADP [nucleoplasm]
p38MAPK phosphorylates MSK1 (Caenorhabditis elegans)
ADP [nucleoplasm]
activated TAK1 mediates p38 MAPK activation (Caenorhabditis elegans)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Caenorhabditis elegans)
ADP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Caenorhabditis elegans)
ADP [nucleoplasm]
Toll Like Receptor 3 (TLR3) Cascade (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
Activation of the AP-1 family of transcription factors (Caenorhabditis elegans)
Activated JNKs phosphorylate c-JUN (Caenorhabditis elegans)
ADP [nucleoplasm]
Phosphorylated MAPKs phosphorylate ATF-2 (Caenorhabditis elegans)
ADP [nucleoplasm]
c-FOS activation by phospho ERK1/2 (Caenorhabditis elegans)
ADP [nucleoplasm]
CREB phosphorylation (Caenorhabditis elegans)
MAPKAPK2 phosphorylates CREB at Serine 133 (Caenorhabditis elegans)
ADP [nucleoplasm]
MSK1 activates ATF1 (Caenorhabditis elegans)
ADP [nucleoplasm]
MSK1 activates CREB (Caenorhabditis elegans)
ADP [nucleoplasm]
RSK1/2/3 phosphorylates CREB at Serine 119 (Caenorhabditis elegans)
ADP [nucleoplasm]
ERK/MAPK targets (Caenorhabditis elegans)
ERK1/2 phosphorylates MSK1 (Caenorhabditis elegans)
ADP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Caenorhabditis elegans)
ADP [nucleoplasm]
p38MAPK phosphorylates MSK1 (Caenorhabditis elegans)
ADP [nucleoplasm]
activated TAK1 mediates p38 MAPK activation (Caenorhabditis elegans)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Caenorhabditis elegans)
ADP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Caenorhabditis elegans)
ADP [nucleoplasm]
Toll Like Receptor 4 (TLR4) Cascade (Caenorhabditis elegans)
MyD88-independent TLR4 cascade (Caenorhabditis elegans)
TRIF (TICAM1)-mediated TLR4 signaling (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
Activation of the AP-1 family of transcription factors (Caenorhabditis elegans)
Activated JNKs phosphorylate c-JUN (Caenorhabditis elegans)
ADP [nucleoplasm]
Phosphorylated MAPKs phosphorylate ATF-2 (Caenorhabditis elegans)
ADP [nucleoplasm]
c-FOS activation by phospho ERK1/2 (Caenorhabditis elegans)
ADP [nucleoplasm]
CREB phosphorylation (Caenorhabditis elegans)
MAPKAPK2 phosphorylates CREB at Serine 133 (Caenorhabditis elegans)
ADP [nucleoplasm]
MSK1 activates ATF1 (Caenorhabditis elegans)
ADP [nucleoplasm]
MSK1 activates CREB (Caenorhabditis elegans)
ADP [nucleoplasm]
RSK1/2/3 phosphorylates CREB at Serine 119 (Caenorhabditis elegans)
ADP [nucleoplasm]
ERK/MAPK targets (Caenorhabditis elegans)
ERK1/2 phosphorylates MSK1 (Caenorhabditis elegans)
ADP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Caenorhabditis elegans)
ADP [nucleoplasm]
p38MAPK phosphorylates MSK1 (Caenorhabditis elegans)
ADP [nucleoplasm]
activated TAK1 mediates p38 MAPK activation (Caenorhabditis elegans)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Caenorhabditis elegans)
ADP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Caenorhabditis elegans)
ADP [nucleoplasm]
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
Activation of the AP-1 family of transcription factors (Caenorhabditis elegans)
Activated JNKs phosphorylate c-JUN (Caenorhabditis elegans)
ADP [nucleoplasm]
Phosphorylated MAPKs phosphorylate ATF-2 (Caenorhabditis elegans)
ADP [nucleoplasm]
c-FOS activation by phospho ERK1/2 (Caenorhabditis elegans)
ADP [nucleoplasm]
CREB phosphorylation (Caenorhabditis elegans)
MAPKAPK2 phosphorylates CREB at Serine 133 (Caenorhabditis elegans)
ADP [nucleoplasm]
MSK1 activates ATF1 (Caenorhabditis elegans)
ADP [nucleoplasm]
MSK1 activates CREB (Caenorhabditis elegans)
ADP [nucleoplasm]
RSK1/2/3 phosphorylates CREB at Serine 119 (Caenorhabditis elegans)
ADP [nucleoplasm]
ERK/MAPK targets (Caenorhabditis elegans)
ERK1/2 phosphorylates MSK1 (Caenorhabditis elegans)
ADP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Caenorhabditis elegans)
ADP [nucleoplasm]
p38MAPK phosphorylates MSK1 (Caenorhabditis elegans)
ADP [nucleoplasm]
activated TAK1 mediates p38 MAPK activation (Caenorhabditis elegans)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Caenorhabditis elegans)
ADP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Caenorhabditis elegans)
ADP [nucleoplasm]
Toll Like Receptor 5 (TLR5) Cascade (Caenorhabditis elegans)
MyD88 cascade initiated on plasma membrane (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
Activation of the AP-1 family of transcription factors (Caenorhabditis elegans)
Activated JNKs phosphorylate c-JUN (Caenorhabditis elegans)
ADP [nucleoplasm]
Phosphorylated MAPKs phosphorylate ATF-2 (Caenorhabditis elegans)
ADP [nucleoplasm]
c-FOS activation by phospho ERK1/2 (Caenorhabditis elegans)
ADP [nucleoplasm]
CREB phosphorylation (Caenorhabditis elegans)
MAPKAPK2 phosphorylates CREB at Serine 133 (Caenorhabditis elegans)
ADP [nucleoplasm]
MSK1 activates ATF1 (Caenorhabditis elegans)
ADP [nucleoplasm]
MSK1 activates CREB (Caenorhabditis elegans)
ADP [nucleoplasm]
RSK1/2/3 phosphorylates CREB at Serine 119 (Caenorhabditis elegans)
ADP [nucleoplasm]
ERK/MAPK targets (Caenorhabditis elegans)
ERK1/2 phosphorylates MSK1 (Caenorhabditis elegans)
ADP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Caenorhabditis elegans)
ADP [nucleoplasm]
p38MAPK phosphorylates MSK1 (Caenorhabditis elegans)
ADP [nucleoplasm]
activated TAK1 mediates p38 MAPK activation (Caenorhabditis elegans)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Caenorhabditis elegans)
ADP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Caenorhabditis elegans)
ADP [nucleoplasm]
Toll Like Receptor 7/8 (TLR7/8) Cascade (Caenorhabditis elegans)
MyD88 dependent cascade initiated on endosome (Caenorhabditis elegans)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
Activation of the AP-1 family of transcription factors (Caenorhabditis elegans)
Activated JNKs phosphorylate c-JUN (Caenorhabditis elegans)
ADP [nucleoplasm]
Phosphorylated MAPKs phosphorylate ATF-2 (Caenorhabditis elegans)
ADP [nucleoplasm]
c-FOS activation by phospho ERK1/2 (Caenorhabditis elegans)
ADP [nucleoplasm]
CREB phosphorylation (Caenorhabditis elegans)
MAPKAPK2 phosphorylates CREB at Serine 133 (Caenorhabditis elegans)
ADP [nucleoplasm]
MSK1 activates ATF1 (Caenorhabditis elegans)
ADP [nucleoplasm]
MSK1 activates CREB (Caenorhabditis elegans)
ADP [nucleoplasm]
RSK1/2/3 phosphorylates CREB at Serine 119 (Caenorhabditis elegans)
ADP [nucleoplasm]
ERK/MAPK targets (Caenorhabditis elegans)
ERK1/2 phosphorylates MSK1 (Caenorhabditis elegans)
ADP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Caenorhabditis elegans)
ADP [nucleoplasm]
p38MAPK phosphorylates MSK1 (Caenorhabditis elegans)
ADP [nucleoplasm]
activated TAK1 mediates p38 MAPK activation (Caenorhabditis elegans)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Caenorhabditis elegans)
ADP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Caenorhabditis elegans)
ADP [nucleoplasm]
Toll Like Receptor 9 (TLR9) Cascade (Caenorhabditis elegans)
MyD88 dependent cascade initiated on endosome (Caenorhabditis elegans)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
Activation of the AP-1 family of transcription factors (Caenorhabditis elegans)
Activated JNKs phosphorylate c-JUN (Caenorhabditis elegans)
ADP [nucleoplasm]
Phosphorylated MAPKs phosphorylate ATF-2 (Caenorhabditis elegans)
ADP [nucleoplasm]
c-FOS activation by phospho ERK1/2 (Caenorhabditis elegans)
ADP [nucleoplasm]
CREB phosphorylation (Caenorhabditis elegans)
MAPKAPK2 phosphorylates CREB at Serine 133 (Caenorhabditis elegans)
ADP [nucleoplasm]
MSK1 activates ATF1 (Caenorhabditis elegans)
ADP [nucleoplasm]
MSK1 activates CREB (Caenorhabditis elegans)
ADP [nucleoplasm]
RSK1/2/3 phosphorylates CREB at Serine 119 (Caenorhabditis elegans)
ADP [nucleoplasm]
ERK/MAPK targets (Caenorhabditis elegans)
ERK1/2 phosphorylates MSK1 (Caenorhabditis elegans)
ADP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Caenorhabditis elegans)
ADP [nucleoplasm]
p38MAPK phosphorylates MSK1 (Caenorhabditis elegans)
ADP [nucleoplasm]
activated TAK1 mediates p38 MAPK activation (Caenorhabditis elegans)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Caenorhabditis elegans)
ADP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Caenorhabditis elegans)
ADP [nucleoplasm]
Metabolism (Caenorhabditis elegans)
Inositol phosphate metabolism (Caenorhabditis elegans)
Synthesis of IPs in the nucleus (Caenorhabditis elegans)
1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Caenorhabditis elegans)
ADP [nucleoplasm]
5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Caenorhabditis elegans)
ADP [nucleoplasm]
5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Caenorhabditis elegans)
ADP [nucleoplasm]
I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Caenorhabditis elegans)
ADP [nucleoplasm]
I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Caenorhabditis elegans)
ADP [nucleoplasm]
I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Caenorhabditis elegans)
ADP [nucleoplasm]
I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Caenorhabditis elegans)
ADP [nucleoplasm]
I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Caenorhabditis elegans)
ADP [nucleoplasm]
IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Caenorhabditis elegans)
ADP [nucleoplasm]
Metabolism of lipids (Caenorhabditis elegans)
Phospholipid metabolism (Caenorhabditis elegans)
PI Metabolism (Caenorhabditis elegans)
Synthesis of PIPs in the nucleus (Caenorhabditis elegans)
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Caenorhabditis elegans)
ADP [nucleoplasm]
Metabolism of nucleotides (Caenorhabditis elegans)
Interconversion of nucleotide di- and triphosphates (Caenorhabditis elegans)
AK6 phosphorylates (d)NMPs to (d)NDPs (Caenorhabditis elegans)
(d)NDPs [nucleoplasm]
ADP [nucleoplasm]
ADP [nucleoplasm]
Metabolism of RNA (Caenorhabditis elegans)
Processing of Capped Intron-Containing Pre-mRNA (Caenorhabditis elegans)
Transport of Mature Transcript to Cytoplasm (Caenorhabditis elegans)
Transport of Mature mRNA derived from an Intron-Containing Transcript (Caenorhabditis elegans)
NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Caenorhabditis elegans)
DDX39B:ADP [nucleoplasm] (Caenorhabditis elegans)
ADP [nucleoplasm]
mRNA Splicing (Caenorhabditis elegans)
mRNA Splicing - Major Pathway (Caenorhabditis elegans)
Formation of the Spliceosomal C* complex (Caenorhabditis elegans)
ADP [nucleoplasm]
Neuronal System (Caenorhabditis elegans)
Transmission across Chemical Synapses (Caenorhabditis elegans)
Neurotransmitter receptors and postsynaptic signal transmission (Caenorhabditis elegans)
Activation of NMDA receptors and postsynaptic events (Caenorhabditis elegans)
Post NMDA receptor activation events (Caenorhabditis elegans)
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling (Caenorhabditis elegans)
Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) (Caenorhabditis elegans)
ADP [nucleoplasm]
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde (Caenorhabditis elegans)
CaMKK autophosphorylates in the nucleus (Caenorhabditis elegans)
ADP [nucleoplasm]
Signal Transduction (Caenorhabditis elegans)
Intracellular signaling by second messengers (Caenorhabditis elegans)
DAG and IP3 signaling (Caenorhabditis elegans)
CaM pathway (Caenorhabditis elegans)
Calmodulin induced events (Caenorhabditis elegans)
CaMK IV-mediated phosphorylation of CREB (Caenorhabditis elegans)
CaMKK autophosphorylates in the nucleus (Caenorhabditis elegans)
ADP [nucleoplasm]
PIP3 activates AKT signaling (Caenorhabditis elegans)
AKT phosphorylates targets in the nucleus (Caenorhabditis elegans)
AKT can phosphorylate NR4A1 (NUR77) (Caenorhabditis elegans)
ADP [nucleoplasm]
AKT can phosphorylate RSK (Caenorhabditis elegans)
ADP [nucleoplasm]
AKT phosphorylates CREB1 (Caenorhabditis elegans)
ADP [nucleoplasm]
AKT phosphorylates FOXO transcription factors (Caenorhabditis elegans)
ADP [nucleoplasm]
MAPK family signaling cascades (Caenorhabditis elegans)
MAPK6/MAPK4 signaling (Caenorhabditis elegans)
CDK1 phosphorylates MAPK6 (Caenorhabditis elegans)
ADP [nucleoplasm]
Signaling by GPCR (Caenorhabditis elegans)
GPCR downstream signalling (Caenorhabditis elegans)
G alpha (i) signalling events (Caenorhabditis elegans)
Opioid Signalling (Caenorhabditis elegans)
G-protein mediated events (Caenorhabditis elegans)
PLC beta mediated events (Caenorhabditis elegans)
Ca-dependent events (Caenorhabditis elegans)
CaM pathway (Caenorhabditis elegans)
Calmodulin induced events (Caenorhabditis elegans)
CaMK IV-mediated phosphorylation of CREB (Caenorhabditis elegans)
CaMKK autophosphorylates in the nucleus (Caenorhabditis elegans)
ADP [nucleoplasm]
G alpha (q) signalling events (Caenorhabditis elegans)
Gastrin-CREB signalling pathway via PKC and MAPK (Caenorhabditis elegans)
ERK1/2/5 activate RSK1/2/3 (Caenorhabditis elegans)
ADP [nucleoplasm]
RSK1/2/3 phosphorylates CREB at Serine 119 (Caenorhabditis elegans)
ADP [nucleoplasm]
Signaling by NOTCH (Caenorhabditis elegans)
Pre-NOTCH Expression and Processing (Caenorhabditis elegans)
Pre-NOTCH Transcription and Translation (Caenorhabditis elegans)
PRKCI phosphorylates ELF3 (Caenorhabditis elegans)
ADP [nucleoplasm]
Signaling by Non-Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by PTK6 (Caenorhabditis elegans)
PTK6 Regulates Proteins Involved in RNA Processing (Caenorhabditis elegans)
PTK6 phosphorylates SFPQ (Caenorhabditis elegans)
ADP [nucleoplasm]
Signaling by Nuclear Receptors (Caenorhabditis elegans)
ESR-mediated signaling (Caenorhabditis elegans)
Estrogen-dependent gene expression (Caenorhabditis elegans)
p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Caenorhabditis elegans)
ADP [nucleoplasm]
Extra-nuclear estrogen signaling (Caenorhabditis elegans)
Estrogen-dependent nuclear events downstream of ESR-membrane signaling (Caenorhabditis elegans)
AKT phosphorylates CREB1 (Caenorhabditis elegans)
ADP [nucleoplasm]
AKT phosphorylates FOXO3 downstream of ESR1 and EGFR (Caenorhabditis elegans)
ADP [nucleoplasm]
Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by NTRKs (Caenorhabditis elegans)
Signaling by NTRK1 (TRKA) (Caenorhabditis elegans)
Nuclear Events (kinase and transcription factor activation) (Caenorhabditis elegans)
CREB phosphorylation (Caenorhabditis elegans)
MAPKAPK2 phosphorylates CREB at Serine 133 (Caenorhabditis elegans)
ADP [nucleoplasm]
MSK1 activates ATF1 (Caenorhabditis elegans)
ADP [nucleoplasm]
MSK1 activates CREB (Caenorhabditis elegans)
ADP [nucleoplasm]
RSK1/2/3 phosphorylates CREB at Serine 119 (Caenorhabditis elegans)
ADP [nucleoplasm]
ERK/MAPK targets (Caenorhabditis elegans)
ERK1/2 phosphorylates MSK1 (Caenorhabditis elegans)
ADP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Caenorhabditis elegans)
ADP [nucleoplasm]
p38MAPK phosphorylates MSK1 (Caenorhabditis elegans)
ADP [nucleoplasm]
NGF-stimulated transcription (Caenorhabditis elegans)
SGK phosphorylates CREB1 (Caenorhabditis elegans)
ADP [nucleoplasm]
SGK phosphorylates SRF (Caenorhabditis elegans)
ADP [nucleoplasm]
Signaling by TGFB family members (Caenorhabditis elegans)
Signaling by TGF-beta Receptor Complex (Caenorhabditis elegans)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Caenorhabditis elegans)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Caenorhabditis elegans)
Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Caenorhabditis elegans)
ADP [nucleoplasm]
Signaling by WNT (Caenorhabditis elegans)
Beta-catenin independent WNT signaling (Caenorhabditis elegans)
Ca2+ pathway (Caenorhabditis elegans)
NLK phosphorylates TCF/LEF (Caenorhabditis elegans)
ADP [nucleoplasm]
Cell Cycle (Canis familiaris)
Cell Cycle Checkpoints (Canis familiaris)
G1/S DNA Damage Checkpoints (Canis familiaris)
p53-Dependent G1/S DNA damage checkpoint (Canis familiaris)
p53-Dependent G1 DNA Damage Response (Canis familiaris)
Stabilization of p53 (Canis familiaris)
ATM phosphorylates MDM2 (Canis familiaris)
ADP [nucleoplasm]
ATM phosphorylates TP53 at S15 (Canis familiaris)
ADP [nucleoplasm]
Autodegradation of the E3 ubiquitin ligase COP1 (Canis familiaris)
Phosphorylation of COP1 at Ser-387 by ATM (Canis familiaris)
ADP [nucleoplasm]
CHEK2 phosphorylates TP53 (Canis familiaris)
ADP [nucleoplasm]
Phosphorylation of MDM4 by ATM (Canis familiaris)
ADP [nucleoplasm]
Phosphorylation of MDM4 by CHEK2 (Canis familiaris)
ADP [nucleoplasm]
p53-Independent G1/S DNA damage checkpoint (Canis familiaris)
p53-Independent DNA Damage Response (Canis familiaris)
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A (Canis familiaris)
Phosphorylation of Cdc25A at Ser-123 by Chk1 (Canis familiaris)
ADP [nucleoplasm]
Phosphorylation of Cdc25A at Ser-123 by Chk2 (Canis familiaris)