Reactome | PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus

PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus

Stable Identifier

R-HSA-6811522

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Acetylation (Homo sapiens)
        
        PI5P Regulates TP53 Acetylation (Homo sapiens)
        
        PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Homo sapiens)

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PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus

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In the nucleus, phosphatidylinositol 5-phosphate (PI5P) is phosphorylated to phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) mainly by phosphatidylinositol-5-phosphate 4-kinase type-2 beta (PIP4K2B). In the nucleus, PIP4K2B predominantly functions as a homodimer or a heterodimer with PIP4K2A. A low level of PIP4K2A homodimers can also be found in the nucleus. Nuclear localization of PIP4K2C has not been examined but is assumed to be possible, at least through formation of heterodimers with PIP4K2B (Ciruela et al. 2000, Jones et al. 2006, Bultsma et al. 2010). Under conditions of cellular stress, nuclear PIP4K2B can be phosphorylated by p38 MAP kinases, resulting in PIP4K2B inactivation. The putative p38 target site, serine residue S326 of PIP4K2B, is conserved in PIP4K2A, but the role and mechanism of p38-mediated regulation of PIP4K2 isoforms has not been studied in detail (Jones et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
16949365	Nuclear PtdIns5P as a transducer of stress signaling: an in vivo role for PIP4Kbeta Jones, DR, D'Santos, CS, Bultsma, Y, Heck, AJ, Keune, WJ, Halstead, JR, Divecha, N, Mohammed, S, Elouarrat, D	Mol. Cell	2006
10698683	Nuclear targeting of the beta isoform of type II phosphatidylinositol phosphate kinase (phosphatidylinositol 5-phosphate 4-kinase) by its alpha-helix 7 Ciruela, A, Irvine, RF, Hinchliffe, KA, Divecha, N	Biochem. J.	2000
20583997	PIP4Kbeta interacts with and modulates nuclear localization of the high-activity PtdIns5P-4-kinase isoform PIP4Kalpha Bultsma, Y, Keune, WJ, Divecha, N	Biochem. J.	2010