Reactome | SGK phosphorylates CREB1

SGK phosphorylates CREB1

Stable Identifier

R-HSA-9612501

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by NTRKs (Homo sapiens)
    - Signaling by NTRK1 (TRKA) (Homo sapiens)
      - Nuclear Events (kinase and transcription factor activation) (Homo sapiens)
        
        NGF-stimulated transcription (Homo sapiens)
        
        SGK phosphorylates CREB1 (Homo sapiens)

General

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Serum/glucocorticoid-induced kinase (SGK) phosphorylates CREB1 at S133 downstream of mutiple cellular stimuli (Lee et al, 1995; David et al, 2005). SGK activity contributes to EGR1 gene expression by promoting the phosphorylation of CREB1 and SRF transcription factor, both of which have binding sites in the EGR1 promoter (Tyan et al, 2008; Sakomoto et al, 1991; Schwachtgen et al, 2000).

Literature References

PubMed ID	Title	Journal	Year
2052361	5' upstream sequence and genomic structure of the human primary response gene, EGR-1/TIS8 Sakamoto, KM, Bardeleben, C, Yates, KE, Raines, MA, Golde, DW, Gasson, JC	Oncogene	1991
7608156	Transcriptional activation of egr-1 by granulocyte-macrophage colony-stimulating factor but not interleukin 3 requires phosphorylation of cAMP response element-binding protein (CREB) on serine 133 Lee, HJ, Mignacca, RC, Sakamoto, KM	J. Biol. Chem.	1995
15733869	Serum/glucocorticoid-inducible kinase can phosphorylate the cyclic AMP response element binding protein, CREB David, S, Kalb, RG	FEBS Lett.	2005
10826704	Full promoter sequence of human early growth response factor-1 (Egr-1): demonstration of a fifth functional serum response element Schwachtgen, JL, Campbell, CJ, Braddock, M	DNA Seq.	2000
18088355	Serum- and glucocorticoid-inducible kinase 1 enhances zif268 expression through the mediation of SRF and CREB1 associated with spatial memory formation Tyan, SW, Tsai, MC, Lin, CL, Ma, YL, Lee, EH	J. Neurochem.	2008

Participants

Input

Output

Participant Of

hasEvent

NGF-stimulated transcription

Catalyst Activity

Title

protein serine/threonine kinase activity of p-T256,S422-SGK1 [nucleoplasm]

Physical Entity

p-T256,S422-SGK1 [nucleoplasm]

Activity

protein serine/threonine kinase activity (0004674)

Orthologous Events

SGK phosphorylates CREB1 (Caenorhabditis elegans)

SGK phosphorylates CREB1 (Canis familiaris)

SGK phosphorylates CREB1 (Danio rerio)

SGK phosphorylates CREB1 (Gallus gallus)

SGK phosphorylates CREB1 (Mus musculus)

SGK phosphorylates CREB1 (Rattus norvegicus)

SGK phosphorylates CREB1 (Sus scrofa)

SGK phosphorylates CREB1 (Xenopus tropicalis)

Authored

Rothfels, K (2019-08-16)

Reviewed

Aletta, J M (2020-01-17)

Created

Rothfels, K (2018-06-28)