SGK phosphorylates CREB1

Stable Identifier
R-HSA-9612501
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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SGK phosphorylates CREB1
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Serum/glucocorticoid-induced kinase (SGK) phosphorylates CREB1 at S133 downstream of mutiple cellular stimuli (Lee et al, 1995; David et al, 2005). SGK activity contributes to EGR1 gene expression by promoting the phosphorylation of CREB1 and SRF transcription factor, both of which have binding sites in the EGR1 promoter (Tyan et al, 2008; Sakomoto et al, 1991; Schwachtgen et al, 2000).
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of p-T256,S422-SGK1 [nucleoplasm]

Physical Entity
p-T256,S422-SGK1 [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
SGK phosphorylates CREB1 (Caenorhabditis elegans)
SGK phosphorylates CREB1 (Canis familiaris)
SGK phosphorylates CREB1 (Danio rerio)
SGK phosphorylates CREB1 (Gallus gallus)
SGK phosphorylates CREB1 (Mus musculus)
SGK phosphorylates CREB1 (Rattus norvegicus)
SGK phosphorylates CREB1 (Sus scrofa)
Authored
Rothfels, K  (2019-08-16)
Reviewed
Aletta, J M  (2020-01-17)
Created
Rothfels, K  (2018-06-28)
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