Serum/glucocorticoid-induced kinase (SGK) phosphorylates CREB1 at S133 downstream of mutiple cellular stimuli (Lee et al, 1995; David et al, 2005). SGK activity contributes to EGR1 gene expression by promoting the phosphorylation of CREB1 and SRF transcription factor, both of which have binding sites in the EGR1 promoter (Tyan et al, 2008; Sakomoto et al, 1991; Schwachtgen et al, 2000).
Sakamoto, KM, Bardeleben, C, Yates, KE, Raines, MA, Golde, DW, Gasson, JC
Lee, HJ, Mignacca, RC, Sakamoto, KM
David, S, Kalb, RG
Schwachtgen, JL, Campbell, CJ, Braddock, M
Tyan, SW, Tsai, MC, Lin, CL, Ma, YL, Lee, EH
protein serine/threonine kinase activity of p-T256,S422-SGK1 [nucleoplasm]
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