Activated AKT1 phosphorylates Runx2

Stable Identifier
R-NUL-8939977
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Activated AKT1 phosphorylates Runx2
Recombinant human AKT1 phosphorylates recombinant mouse Runx2 isoform 5 (Runx2-5), associated with endogenous human CBFB, at serine residue S203 and threonine residues T205 and T207. AKT1 target sites in Runx2-5 are evolutionarily conserved and match S196, T198 and T200 in human RUNX2. Mouse Runx2-5 is 97% identical to human RUNX2 (Pande et al. 2013).
Literature References
PubMed ID Title Journal Year
23389849 Oncogenic cooperation between PI3K/Akt signaling and transcription factor Runx2 promotes the invasive properties of metastatic breast cancer cells

Pande, S, Browne, G, Padmanabhan, S, Zaidi, SK, Lian, JB, van Wijnen, AJ, Stein, JL, Stein, GS

J. Cell. Physiol. 2013
Participants
Input
Output
Catalyst Activity

protein serine/threonine kinase activity of p-T308,S473-AKT1 [nucleoplasm]

Physical Entity
p-T308,S473-AKT1 [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
Activated AKT phosphorylates RUNX2 (Homo sapiens)
Authored
Orlic-Milacic, M  (2016-09-22)
Reviewed
Ducy, P  (2017-08-04)
Created
Orlic-Milacic, M  (2016-09-22)
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