Inactivation of Wee1 kinase

Stable Identifier
Reaction [transition]
Homo sapiens
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*Plk1 is shown to phosphorylate Wee1A, an event that is likely critical for recognition and ubiquitination of Wee1A by SCF and therefore for the subsequent degradation of Wee1A . **Plk1 phosphorylates Wee1A at S53, creating the second phosphodegron, PD53. ** Evidence also exists in budding yeast that the budding yeast polo homolog Cdc5 directly phosphorylates and down-regulate the budding yeast Wee1 ortholog Swe1. Thus, polo kinase-dependent phosphorylation and degradation of Wee1A (or Swe1) is likely conserved throughout evolution and is critical for normal mitotic entry.

Literature References
PubMed ID Title Journal Year
15070733 M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP

Nishihara, Y, Taniguchi, M, Arai, H, Watanabe, N, Osada, H, Hunter, T, Watanabe, N

Proc Natl Acad Sci U S A 2004
15037762 Coupling morphogenesis to mitotic entry

Park, JE, Lee, KS, Veenstra, TD, Cho, YW, Sakchaisri, K, Yu, LR, Asano, S, Park, CJ, Shulewitz, MJ, Thorner, J

Proc Natl Acad Sci U S A 2004
Event Information
Go Biological Process
Catalyst Activity

protein serine/threonine kinase activity of p-T210-PLK1 [nucleoplasm]

Orthologous Events
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