ATM phosphorylates PIDD1

Stable Identifier
R-HSA-6800490
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
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ATM phosphorylates PIDD1
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In response to DNA damage, activated ATM phosphorylates PIDD1 at threonine residue T788, a prerequisite for the subsequent interaction with CRADD (RAIDD) (Ando et al. 2012).

Literature References
PubMed ID Title Journal Year
22854598 PIDD death-domain phosphorylation by ATM controls prodeath versus prosurvival PIDDosome signaling

Ando, K, Kernan, JL, Liu, PH, Sanda, T, Logette, E, Tschopp, J, Look, AT, Wang, J, Bouchier-Hayes, L, Sidi, S

Mol. Cell 2012
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-S1981,Ac-K3016-ATM [nucleoplasm]
Physical Entity
p-S1981,Ac-K3016-ATM [nucleoplasm]
Activity
protein serine/threonine kinase activity (0004674)
Orthologous Events
ATM phosphorylates PIDD1 (Bos taurus)
ATM phosphorylates PIDD1 (Canis familiaris)
ATM phosphorylates PIDD1 (Danio rerio)
ATM phosphorylates PIDD1 (Gallus gallus)
ATM phosphorylates PIDD1 (Mus musculus)
ATM phosphorylates PIDD1 (Rattus norvegicus)
ATM phosphorylates PIDD1 (Sus scrofa)
ATM phosphorylates PIDD1 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-09-29)