ATM phosphorylates PIDD1

Stable Identifier
R-HSA-6800490
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
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In response to DNA damage, activated ATM phosphorylates PIDD1 at threonine residue T788, a prerequisite for the subsequent interaction with CRADD (RAIDD) (Ando et al. 2012).

Literature References
PubMed ID Title Journal Year
22854598 PIDD death-domain phosphorylation by ATM controls prodeath versus prosurvival PIDDosome signaling

Ando, K, Kernan, JL, Liu, PH, Sanda, T, Logette, E, Tschopp, J, Look, AT, Wang, J, Bouchier-Hayes, L, Sidi, S

Mol. Cell 2012
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-S1981,Ac-K3016-ATM [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created