Reactome | ATM phosphorylates PIDD1

ATM phosphorylates PIDD1

Stable Identifier

R-HSA-6800490

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
        
        TP53 Regulates Transcription of Caspase Activators and Caspases (Homo sapiens)
        
        ATM phosphorylates PIDD1 (Homo sapiens)

General

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In response to DNA damage, activated ATM phosphorylates PIDD1 at threonine residue T788, a prerequisite for the subsequent interaction with CRADD (RAIDD) (Ando et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
22854598	PIDD death-domain phosphorylation by ATM controls prodeath versus prosurvival PIDDosome signaling Ando, K, Kernan, JL, Liu, PH, Sanda, T, Logette, E, Tschopp, J, Look, AT, Wang, J, Bouchier-Hayes, L, Sidi, S	Mol. Cell	2012