Reactome | p-PKR dimer phosphorylates SPHK1

p-PKR dimer phosphorylates SPHK1

Stable Identifier

R-HSA-9836617

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Activated PKR phosphorylates sphingosin kinase 1 (SPHK1) at S225 in the nucleus, priming it for nuclear export. This process is part of a feedback loop between PKR and SPHK1, activating pro-survival pathways in the cellular response to external stimuli (Qiao et al, 2020).

Literature References

PubMed ID	Title	Journal	Year
32801355	Cell fate determined by the activation balance between PKR and SPHK1 Qiao, H, Jiang, T, Mu, P, Chen, X, Wen, X, Hu, Z, Tang, S, Wen, J, Deng, Y	Cell Death Differ	2021