PDPK1 phosphorylates RSKs

Stable Identifier
R-HSA-442739
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
PDPK1 phosphorylates RSKs
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

PDPK1 (PDK1) activates ribosomal S6 kinases (RSKs) by phosphorylating a conserved serine residue S221 (in RPS6KA1). The binding site for PDPK1 on RSKs is available after RSK phosphorylation by MAPKs/ERKs. PDPK1 is present in the activated form at the plasma membrane where the phosphorylation occurs (Jensen et al. 1999).

Literature References
PubMed ID Title Journal Year
10480933 90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1

Jensen, CJ, Buch, MB, Krag, TO, Hemmings, BA, Gammeltoft, S, Frödin, M

J Biol Chem 1999
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of PDPK1:PIP3,PDPK1:PIP2 [plasma membrane]
Physical Entity
PDPK1:PIP3,PDPK1:PIP2 [plasma membrane]
Activity
protein serine/threonine kinase activity (0004674)
Inferred From
PDPK1 phosphorylates Rps6ka2 (Homo sapiens)
Authored
Mahajan, SS  (2009-10-29)
Reviewed
Tukey, D  (2009-11-18)
Yi, F  (2018-11-02)
Hansen, KB  (2018-11-02)
Created
Mahajan, SS  (2009-09-29)
Cite Us!