PDPK1 phosphorylates RSKs

Stable Identifier
R-HSA-442739
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
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PDPK1 phosphorylates RSKs
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PDPK1 (PDK1) activates ribosomal S6 kinases (RSKs) by phosphorylating a conserved serine residue S221 (in RPS6KA1). The binding site for PDPK1 on RSKs is available after RSK phosphorylation by MAPKs/ERKs. PDPK1 is present in the activated form at the plasma membrane where the phosphorylation occurs (Jensen et al. 1999).

Literature References
PubMed ID Title Journal Year
10480933 90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1

Jensen, CJ, Buch, MB, Krag, TO, Hemmings, BA, Gammeltoft, S, Frödin, M

J Biol Chem 1999
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of PDPK1:PIP3,PDPK1:PIP2 [plasma membrane]
Physical Entity
PDPK1:PIP3,PDPK1:PIP2 [plasma membrane]
Activity
protein serine/threonine kinase activity (0004674)
Inferred From
PDPK1 phosphorylates Rps6ka2 (Homo sapiens)
Authored
Mahajan, SS  (2009-10-29)
Reviewed
Tukey, D  (2009-11-18)
Yi, F  (2018-11-02)
Hansen, KB  (2018-11-02)
Created
Mahajan, SS  (2009-09-29)