Phosphorylation of the Emi1 DSGxxS degron by Plk1

Stable Identifier
R-HSA-174174
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The phosphorylation of Emi1 by Plk1 is believed to be involved in the degradation of Emi1 during mitosis. Plk1 phosphorylates serine residues in the DSGxxS degron sequence of Emi1 recruiting the SCF(betaTrCP) ubiquitin ligase.

Literature References
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-T210-PLK1 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created
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