TAF1 phosphorylates TP53

Stable Identifier
R-HSA-6805399
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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TAF1, the largest subunit of the transcription initiation factor TFIID complex, phosphorylates TP53 (p53) at threonine residue T55. TAF1-mediated phosphorylation of TP53 increases affinity of TP53 for the ubiquitin ligase MDM2, thus promoting TP53 degradation (Li et al. 2004).

Literature References
PubMed ID Title Journal Year
15053879 Phosphorylation on Thr-55 by TAF1 mediates degradation of p53: a role for TAF1 in cell G1 progression

Li, HH, Li, AG, Sheppard, HM, Liu, X

Mol. Cell 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of TFIID [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created