TAF1 phosphorylates TP53

Stable Identifier
R-HSA-6805399
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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TAF1 phosphorylates TP53
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TAF1, the largest subunit of the transcription initiation factor TFIID complex, phosphorylates TP53 (p53) at threonine residue T55. TAF1-mediated phosphorylation of TP53 increases affinity of TP53 for the ubiquitin ligase MDM2, thus promoting TP53 degradation (Li et al. 2004).
Literature References
PubMed ID Title Journal Year
15053879 Phosphorylation on Thr-55 by TAF1 mediates degradation of p53: a role for TAF1 in cell G1 progression

Sheppard, HM, Li, HH, Li, AG, Liu, X

Mol. Cell 2004
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of TFIID [nucleoplasm]

Physical Entity
TFIID [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
TAF1 phosphorylates TP53 (Bos taurus)
TAF1 phosphorylates TP53 (Canis familiaris)
TAF1 phosphorylates TP53 (Drosophila melanogaster)
TAF1 phosphorylates TP53 (Mus musculus)
TAF1 phosphorylates TP53 (Rattus norvegicus)
TAF1 phosphorylates TP53 (Sus scrofa)
TAF1 phosphorylates TP53 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-10-19)
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