TAF1 phosphorylates TP53

Stable Identifier
R-HSA-6805399
Type
Reaction
Species
Homo sapiens
Compartment
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TAF1, the largest subunit of the transcription initiation factor TFIID complex, phosphorylates TP53 (p53) at threonine residue T55. TAF1-mediated phosphorylation of TP53 increases affinity of TP53 for the ubiquitin ligase MDM2, thus promoting TP53 degradation (Li et al. 2004).

Literature References
PubMed ID Title Journal Year
15053879 Phosphorylation on Thr-55 by TAF1 mediates degradation of p53: a role for TAF1 in cell G1 progression

Sheppard, HM, Li, HH, Li, AG, Liu, X

Mol. Cell 2004
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of TFIID [nucleoplasm]

Orthologous Events
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