TAF1 phosphorylates TP53

Stable Identifier
R-HSA-6805399
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
TAF1 phosphorylates TP53
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

TAF1, the largest subunit of the transcription initiation factor TFIID complex, phosphorylates TP53 (p53) at threonine residue T55. TAF1-mediated phosphorylation of TP53 increases affinity of TP53 for the ubiquitin ligase MDM2, thus promoting TP53 degradation (Li et al. 2004).

Literature References
PubMed ID Title Journal Year
15053879 Phosphorylation on Thr-55 by TAF1 mediates degradation of p53: a role for TAF1 in cell G1 progression

Li, HH, Li, AG, Sheppard, HM, Liu, X

Mol. Cell 2004
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of TFIID [nucleoplasm]
Physical Entity
TFIID [nucleoplasm]
Activity
protein serine/threonine kinase activity (0004674)
Orthologous Events
TAF1 phosphorylates TP53 (Bos taurus)
TAF1 phosphorylates TP53 (Danio rerio)
TAF1 phosphorylates TP53 (Drosophila melanogaster)
TAF1 phosphorylates TP53 (Mus musculus)
TAF1 phosphorylates TP53 (Rattus norvegicus)
TAF1 phosphorylates TP53 (Sus scrofa)
TAF1 phosphorylates TP53 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-10-19)