ABL1 phosphorylates RAD52

Stable Identifier
R-HSA-5686587
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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ABL1 phosphorylates RAD52
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ABL1 (c-ABL), activated by ATM-mediated phosphorylation in response to DNA double-strand breaks (DSBs), phosphorylates RAD52 on tyrosine residue Y104, thus increasing the affinity of RAD52 heptamer for ssDNA and enhancing the efficiency of RAD52-mediated single strand annealing (SSA) (Honda et al. 2011).

Literature References
PubMed ID Title Journal Year
21804533 Tyrosine phosphorylation enhances RAD52-mediated annealing by modulating its DNA binding

Spies, M, Ha, T, Honda, M, Yoo, J, Okuno, Y

EMBO J. 2011
Participants
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Output
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as an event of
Catalyst Activity

protein tyrosine kinase activity of p-S456-ABL1 [nucleoplasm]

Physical Entity
p-S456-ABL1 [nucleoplasm] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
ABL1 phosphorylates RAD52 (Bos taurus)
ABL1 phosphorylates RAD52 (Canis familiaris)
ABL1 phosphorylates RAD52 (Danio rerio)
ABL1 phosphorylates RAD52 (Gallus gallus)
ABL1 phosphorylates RAD52 (Mus musculus)
ABL1 phosphorylates RAD52 (Rattus norvegicus)
ABL1 phosphorylates RAD52 (Sus scrofa)
ABL1 phosphorylates RAD52 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2015-05-12)
Reviewed
Borowiec, JA  (2015-06-12)
Created
Orlic-Milacic, M  (2015-04-02)
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