ABL1 (c-ABL), activated by ATM-mediated phosphorylation in response to DNA double strand breaks (DSBs), phosphorylates RAD52 on tyrosine residue Y104, thus increasing the affinity of RAD52 heptamer for ssDNA and enhancing the efficiency of RAD52-mediated single strand annealing (SSA) (Honda et al. 2011).
Honda, M, Okuno, Y, Yoo, J, Ha, T, Spies, M
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