ABL1 phosphorylates RAD52

Stable Identifier
R-HSA-5686587
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

ABL1 (c-ABL), activated by ATM-mediated phosphorylation in response to DNA double strand breaks (DSBs), phosphorylates RAD52 on tyrosine residue Y104, thus increasing the affinity of RAD52 heptamer for ssDNA and enhancing the efficiency of RAD52-mediated single strand annealing (SSA) (Honda et al. 2011).

Literature References
PubMed ID Title Journal Year
21804533 Tyrosine phosphorylation enhances RAD52-mediated annealing by modulating its DNA binding

Honda, M, Okuno, Y, Yoo, J, Ha, T, Spies, M

EMBO J. 2011
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of p-S456-ABL1 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created