ABL1 phosphorylates RAD52

Stable Identifier
R-HSA-5686587
Type
Reaction
Species
Homo sapiens
Compartment
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ABL1 (c-ABL), activated by ATM-mediated phosphorylation in response to DNA double-strand breaks (DSBs), phosphorylates RAD52 on tyrosine residue Y104, thus increasing the affinity of RAD52 heptamer for ssDNA and enhancing the efficiency of RAD52-mediated single strand annealing (SSA) (Honda et al. 2011).

Literature References
PubMed ID Title Journal Year
21804533 Tyrosine phosphorylation enhances RAD52-mediated annealing by modulating its DNA binding

Spies, M, Ha, T, Honda, M, Yoo, J, Okuno, Y

EMBO J. 2011
Participants
Participates
Catalyst Activity

protein tyrosine kinase activity of p-S456-ABL1 [nucleoplasm]

Orthologous Events
Authored
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