ABL1 (c-ABL), activated by ATM-mediated phosphorylation in response to DNA double-strand breaks (DSBs), phosphorylates RAD52 on tyrosine residue Y104, thus increasing the affinity of RAD52 heptamer for ssDNA and enhancing the efficiency of RAD52-mediated single strand annealing (SSA) (Honda et al. 2011).
Spies, M, Ha, T, Honda, M, Yoo, J, Okuno, Y
protein tyrosine kinase activity of p-S456-ABL1 [nucleoplasm]
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