CDK5 phosphorylates TP53

Stable Identifier
R-HSA-6805276
Type
Reaction
Species
Homo sapiens
Compartment
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CDK5, in complex with cleaved CDK5R1 (p25), which ensures nuclear localization (Patrick et al. 1999, Lee et al. 2008), phosphorylates TP53 (p53) on serine residues S15, S33 and S46. CDK5-mediated phosphorylation of TP53 promotes transcription of pro-apoptotic genes and neuronal cell death (Zhang et al. 2002, Lee et al. 2007, Lee et al. 2008).

Literature References
PubMed ID Title Journal Year
10604467 Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

Dikkes, P, Patrick, GN, Nikolic, M, Zukerberg, L, Tsai, LH, de la Monte, S

Nature 1999
17591690 Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death

Kim, HS, Lee, SJ, Lee, JH, Kim, KT

J. Cell. Sci. 2007
12064478 Cdk5 phosphorylates p53 and regulates its activity

Krishnamurthy, PK, Johnson, GV, Zhang, J

J. Neurochem. 2002
10500146 Regulation of cyclin-dependent kinase 5 catalytic activity by phosphorylation

Albers, RW, Sharma, M, Sharma, P, Pant, HC, Amin, ND

Proc. Natl. Acad. Sci. U.S.A. 1999
18490454 Cooperative roles of c-Abl and Cdk5 in regulation of p53 in response to oxidative stress

Choi, YH, Lee, JH, Kim, KT, Kim, W, Jeong, MW

J. Biol. Chem. 2008
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of p-Y15,S159-CDK5:CDK5R1 (99-307) [nucleoplasm]

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