ATM phosphorylates HERC2

Stable Identifier
R-HSA-5682598
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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ATM phosphorylates HERC2 on threonine residue T4827. This threonine residue may also be phosphorylated by ATR and DNA-PKcs (PRKDC) (Bekker-Jensen et al. 2010).

Literature References
PubMed ID Title Journal Year
20023648 HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes

Bekker-Jensen, S, Rendtlew Danielsen, J, Fugger, K, Gromova, I, Nerstedt, A, Lukas, C, Bartek, J, Lukas, J, Mailand, N

Nat. Cell Biol. 2010
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:HERC2:PIAS4 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created