AKT phosphorylates CBY1

Stable Identifier
R-HSA-3769394
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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CBY1 is phosphorylated in vitro at serine 20 by AKT1 and AKT2. In vivo, this phosphorylation is required for the export of beta-catenin from the nucleus, facilitated by the binding of 14-3-3/YWHAZ proteins to the pS20 residue of CBY1 (Li et al, 2008).

Literature References
PubMed ID Title Journal Year
18573912 Chibby cooperates with 14-3-3 to regulate beta-catenin subcellular distribution and signaling activity

Li, FQ, Mofunanya, A, Harris, K, Takemaru, K

J. Cell Biol. 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-AKT1/2 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created