ATM phosphorylates EYA1-4

Stable Identifier
R-HSA-5683964
Type
Reaction [transition]
Species
Homo sapiens
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EYA tyrosine protein phosphatases (EYA1, EYA2 and EYA3) play an important role in repair of DNA double strand breaks (DSBs) (Cook et al. 2009, Krishnan et al. 2009). The role of EYA4 in the context of DNA damage has not been examined but is plausible based on sequence similarity. EYA3 is phosphorylated by activated ATM on serine residue S266 (labeled as S219 by Cook et al. 2009) and this phosphorylation is important for the catalytic activity of EYA3 (Cook et al. 2009). Although EYA1, EYA2 and EYA4 possess several sites that match the ATM consensus SQ/TQ sequence, their phosphorylation by ATM has not been examined

Literature References
PubMed ID Title Journal Year
19234442 Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions

Cook, PJ, Ju, BG, Telese, F, Wang, X, Glass, CK, Rosenfeld, MG

Nature 2009
19351884 Dephosphorylation of the C-terminal tyrosyl residue of the DNA damage-related histone H2A.X is mediated by the protein phosphatase eyes absent

Krishnan, N, Jeong, DG, Jung, SK, Ryu, SE, Xiao, A, Allis, CD, Kim, SJ, Tonks, NK

J. Biol. Chem. 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm]
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Orthologous Events
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