Reactome | ATM phosphorylates EYA1-4

ATM phosphorylates EYA1-4

Stable Identifier

R-HSA-5683964

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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EYA tyrosine protein phosphatases (EYA1, EYA2 and EYA3) play an important role in repair of DNA double-strand breaks (DSBs) (Cook et al. 2009, Krishnan et al. 2009). The role of EYA4 in the context of DNA damage has not been examined but is plausible based on sequence similarity. EYA3 is phosphorylated by activated ATM on serine residue S266 (labeled as S219 by Cook et al. 2009) and this phosphorylation is important for the catalytic activity of EYA3 (Cook et al. 2009). Although EYA1, EYA2 and EYA4 possess several sites that match the ATM consensus SQ/TQ sequence, their phosphorylation by ATM has not been examined

Literature References

PubMed ID	Title	Journal	Year
19351884	Dephosphorylation of the C-terminal tyrosyl residue of the DNA damage-related histone H2A.X is mediated by the protein phosphatase eyes absent Krishnan, N, Jeong, DG, Jung, SK, Ryu, SE, Xiao, A, Allis, CD, Kim, SJ, Tonks, NK	J. Biol. Chem.	2009
19234442	Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions Cook, PJ, Ju, BG, Telese, F, Wang, X, Glass, CK, Rosenfeld, MG	Nature	2009