Reactome | MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB

MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB

Stable Identifier

R-HSA-3857329

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB

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Phosphorylation of CEBPB (C/EBP-beta) transcription factor on threonine residue T235 happens downstream of activated RAS, is mediated by MAPKs - likely MAPK3 (ERK1) and MAPK1 (ERK2), and positively affects CEBPB-mediated transcription of IL6 (Nakajima et al. 1993).

Literature References

PubMed ID	Title	Journal	Year
8384717	Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6 Kinoshita, S, Kishimoto, T, Nakajima, T, Akira, S, Naruto, M, Sasaki, K, Sasagawa, T	Proc. Natl. Acad. Sci. U.S.A.	1993