Phosphorylation of Cdc25C at Ser216 by CHEK2

Stable Identifier
R-HSA-75809
Type
Reaction
Species
Homo sapiens
Compartment
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Cdc25C is negatively regulated by phosphorylation on Ser 216, the 14-3-3-binding site. This is an important regulatory mechanism used by cells to block mitotic entry under normal conditions and after DNA damage (Chaturvedi et al, 1999; Bulavin et al., 2003).

Literature References
PubMed ID Title Journal Year
10435585 Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway

Carr, SA, Winkler, JD, Mattern, MR, Zhou, BB, Johnson, RK, Chaturvedi, P, Li, X, Lu, Q, Zhu, Y, Annan, RS, Zhang, X, Scott, GF, Faucette, LF, Eng, WK, Hurle, MR, Mishra, R

Oncogene 1999
12766774 Dual phosphorylation controls Cdc25 phosphatases and mitotic entry

Higashimoto, Y, Fornace AJ, Jr, Zhao, H, Moody, SA, Phillips, C, Appella, E, Bulavin, DV, Meek, S, Demidenko, ZN, Piwnica-Worms, H, Graves, P

Nat Cell Biol 2003
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of p-S,3T-CHEK2 [nucleoplasm]

Orthologous Events
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